Project Grant R01HL174649

Award Date 9/1/25
Completion Date 5/31/29
Dollars Obligated $688K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $688,163 to the University of Pittsburgh to investigate the role of indole metabolites as danger signals that contribute to acute lung injury and the development of acute respiratory distress syndrome (ARDS).

The research aims to: 1) determine the mechanism by which indole metabolites derived from microbes cause cell death in lung epithelial cells, 2) evaluate the protective effects of cAMP signaling against indole metabolite toxicity, and 3) assess the ex vivo toxicity of indole metabolites on human lungs and their association with hyperinflammatory respiratory failure and clinical outcomes. This work is expected to advance the understanding of how metabolites can act as danger signals to drive regulated cell death and innate immune activation in the lungs, potentially leading to new therapeutic approaches for ARDS.

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