This $775,992 five-year Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of North Carolina at Chapel Hill (UNC-CH) to investigate the role of regulatory T cells (Tregs) and glucocorticoids in lung injury and repair. The overall goal is to elucidate the mechanisms by which glucocorticoid signaling through Tregs contributes to the resolution of acute lung injury and the impact of host genetic variation on these processes. Key objectives include: 1) determining the function of Treg glucocorticoid receptor signaling and the direct/indirect effects of exogenous glucocorticoids on Treg-mediated lung repair; and 2) leveraging a genetically diverse mouse population to identify genetic loci associated with Treg responses and glucocorticoid effects during acute lung injury resolution. This research may inform the development of novel therapeutic approaches to mitigate tissue damage from acute lung injuries.
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