This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, provides $200,502 to support research under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The primary objective is to identify metabolite and protein drivers of acute respiratory distress syndrome (ARDS) evolution in patients with hyper-inflammatory and hypo-inflammatory ARDS subtypes. The research, conducted by the University of...
This $1,147,992 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to advance precision medicine for acute respiratory distress syndrome (ARDS) and sepsis. The research aims to address key unanswered questions about the functional immune response and pathogens driving the hyperinflammatory and hypoinflammatory phenotypes of these conditions, identify potential druggable targets, and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, will support research to determine how alveolar macrophage (AM) subset ontogeny and function contribute to clinical outcomes in acute respiratory distress syndrome (ARDS). The $730,876 award to the University of Washington will fund a 5-year study with the following key objectives: Aim 1 will leverage AM chimerism in lung transplant recipients...
This $480,990 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to investigate the role of "aerocytes" - a specialized capillary endothelial cell population - in facilitating alveolar epithelial regeneration following lung injury associated with acute respiratory distress syndrome (ARDS). The research, conducted by the University of Illinois, will focus on understanding how...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), supports research under the Cardiovascular Diseases Research program (CFDA 93.837). The primary objective is to develop and validate an automated electronic health record (EHR)-embedded system that can rapidly classify molecular phenotypes of critical illnesses like acute respiratory distress syndrome (ARDS) and sepsis at the bedside. This will enable future...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $616,000.00 to Northwestern University over a 5-year period beginning September 1, 2024. The grant supports research to investigate the role of mitochondrial metabolism and the integrated stress response in alveolar epithelial cell differentiation, with the goal of understanding the mechanisms driving heterogeneous outcomes in...
This $386,692 Project Grant was awarded on June 19, 2024 by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837). The funding supports research to develop a cell-based therapy for treating acute respiratory distress syndrome (ARDS) by engineering T cells to secrete growth factors that promote regeneration of the lung epithelium. The key objectives are to evaluate in vitro and in vivo the ability of engineered T cells to deliver...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA Program 93.837 - Cardiovascular Diseases Research provides $777,048 to support research at The Trustees of Columbia University in the City of New York, Health Sciences Division. The research aims to better understand how enhancing gap junctional channels between alveolar myeloid cells and the alveolar epithelium can improve host resilience against acute lung injury (ALI) and acute respiratory...
This $1,875,540 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to investigate the role of perivascular macrophages in promoting endothelial cell regeneration and vascular repair following acute lung injury or acute respiratory distress syndrome (ARDS). The key objectives are to (1) determine how perivascular macrophages regulate endothelial cell regeneration and vascular repair...
This $782,362 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research on the role of TREK-1 potassium channels in acute respiratory distress syndrome (ARDS). The research aims to: Investigate whether influenza A virus, alone and combined with hyperoxia and mechanical ventilation, decreases epithelial and endothelial TREK-1 levels, accelerating lung injury in ARDS. Determine if...