This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 "Cardiovascular Diseases Research" will provide $126,059 from September 1, 2024 to August 31, 2029 to the University of Colorado-Denver. The project aims to use proteomics and metabolomics approaches to study the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). Specifically, the project will measure changes in the circulating...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,057,973 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to The Johns Hopkins University to conduct research on modeling fetal lung development in congenital diaphragmatic hernia (CDH). The research aims to investigate the role of the YAP/TAZ mechanosensing pathway in CDH lung hypoplasia using mouse models, human lung organoids, and large animal fetal models. The research teams led by Shaun Kunisaki, Jason...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $844,386 to support research on the genetic landscape of childhood interstitial and diffuse lung diseases (CHILD). The key objectives are to: 1) Define molecular profiles of 300 CHILD lung biopsy samples to identify patient clusters with similar underlying causes, 2) Analyze whole exome sequence data from 400 children with...
This Project Grant award of $696,470.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Denver to investigate the relationship between prenatal maternal sleep and offspring cardiovascular disease risk. The research aims to: 1) examine how prenatal maternal sleep trajectories predict maternal biological pathways like inflammation and stress, 2) assess how prenatal maternal sleep impacts offspring growth,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, will provide $267,000 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) from August 1, 2025 to July 31, 2027. The goal of this project is to identify shared genetic mechanisms that disrupt both heart and brain development in individuals with congenital heart disease (CHD) and neurodevelopmental delays (NDD). The...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $234,000.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct secondary analysis of noninvasive imaging biomarkers for early prediction of single ventricle heart disease (SVD) failure. The project aims to noninvasively quantify systemic and pulmonary vascular compliance through...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research, will establish patient-reported outcome measures to refine risk stratification and identify barriers to post-discharge specialty care for preterm infants with bronchopulmonary dysplasia (BPD). The $586,021 award to the Medical College of Wisconsin, Inc. will link neonatal intensive care unit data to mobile-enabled parent-reported...
This $392,882 Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will support research by Dr. Brandon Smith at The Johns Hopkins University to address racial disparities in chronic lung disease (CLD) for preterm infants. The key objectives are to: 1) characterize medical and social determinant profiles of preterm infants with CLD and identify high-risk groups, 2) describe the lived experiences of...
The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $802,500 Cooperative Agreement grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports the construction of a multi-scale 3D AI-powered map of genetic factors and cellular interactions driving normal and aberrant lung development in childhood interstitial lung disease (CHILD). The project will leverage single-cell and spatial...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $179,330 to the Research Institute at Nationwide Children's Hospital to conduct research aimed at identifying biomarkers that can predict disease progression and weaning outcomes in infants with severe bronchopulmonary dysplasia (BPD). The goal is to develop biomarker-informed prognostic models and assess the feasibility of a biomarker-driven clinical trial of...