The National Heart, Lung, and Blood Institute (NHLBI) awarded a $742,395 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Case Western Reserve University (CWRU) to develop and validate a comprehensive machine learning-based analysis of coronary artery calcium scoring (CTCS) scans to identify key image-based biomarkers (radiomics) corresponding to pathophysiologic domains linked with heart failure (HF) risk. The goal is to create a reliable and reproducible CTCS-based HF-specific...
This Project Grant award of $810,650 from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at Cedars-Sinai Medical Center to develop and validate an AI-enabled algorithm for characterizing fibrotic and calcific aortic valve tissue from computed tomography angiography (CTA) scans. The goal is to predict rapid aortic valve disease progression and patient outcomes following valve replacement surgery. The project...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), awarded a $299,604 project grant to Case Western Reserve University. The 4-year grant, effective September 1, 2024, supports the development and validation of a novel "transfer volume regression" model to enable quantitative clinical risk predictions for major cardiovascular events, including stroke, heart attack, heart failure, and death. The project...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $145,642 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Leland Stanford Junior University (Stanford University) to investigate the molecular mechanisms that regulate mitochondrial calcium uptake. The research aims to advance understanding of mitochondrial calcium signaling, which is heavily implicated in the pathogenesis of heart disease. Through a multidisciplinary approach involving...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, aims to precisely determine if cancer promotes cardiovascular disease and identify potential therapies. The $1,102,957 award to The Leland Stanford Junior University will fund a comprehensive research program across three key areas: 1) mapping causal associations and genetic connections between cancer and cardiovascular disease using...
The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $700,398 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of Columbia University in the City of New York. The grant, awarded on July 1, 2024, will fund research to integrate spatial transcriptomics, genetics, and histomorphology for causal inference in atherosclerotic cardiovascular disease. The research aims to apply novel machine learning algorithms to analyze histology images...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $2,408,580 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to The Leland Stanford Junior University. The grant, titled "Evaluation of the AMPK-BACH1-NRF2 Axis as a Therapeutic Target for Inherited DCM", aims to explore the potential of activating the AMPK-BACH1-NRF2 signaling pathway as a treatment for inherited forms of dilated cardiomyopathy (DCM), a leading cause of heart...
This $641,544 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports the development of novel machine learning methods to address key challenges in analyzing complex biomedical data related to heart, lung, blood, and sleep (HLBS) disorders. Specifically, the project aims to: 1) propose new machine learning techniques for uncovering causal relationships between clinical...
This $167,864 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a study to investigate risk stratification and outcomes across the spectrum of immune checkpoint inhibitor (ICI) cardiotoxicity. The key objectives are to: Retrospectively examine cardiac and oncologic outcomes associated with ICI cardiotoxicity based on patient symptoms and troponin-I measurements. Retrospectively assess the risks of ICI continuation...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $1,557,275 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Utah. The funding will support the development of a novel magnetic resonance imaging (MRI) method to detect coronary artery disease (CAD) in patients with atrial fibrillation (AFib). Specifically, the project aims to create a flow and motion insensitive steady-state (FAMISS)...