The National Heart, Lung, and Blood Institute (NHLBI) awarded a $810,650 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Cedars-Sinai Medical Center. The grant, effective September 1, 2024 through May 31, 2028, aims to develop and validate an artificial intelligence (AI)-enabled system for fully automated quantification of fibrotic and calcific aortic valve tissue characteristics from computed tomography angiography (CTA) scans. The project also seeks to assess the concordance between these aortic valve tissue characteristics and functional valve hemodynamics, as well as to create and validate an AI-powered risk score that integrates patient clinical data, aortic valve tissue characteristics, and peri-aortic vascular inflammation to predict mortality and stroke following valve replacement. This research will enable comprehensive phenotyping of aortic stenosis, potentially leading to image-informed clinical trials of new therapies.