This federal Project Grant award, totaling $456,251.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The overarching goal of the proposed research is to test the hypothesis that pro-inflammatory mediators produced by maternal adipose tissue (leptin) reduce pro-angiogenic immune cells and factors at the maternal-fetal interface, which can contribute to adverse pregnancy outcomes...
This $717,285 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund a large-scale investigation of the vaginal ecosystem and its potential role in preeclampsia. The project aims to uncover the microbial, metabolomic, and immune properties of the vaginal microbiome that may indicate, predispose to, or contribute to the development of preeclampsia, a serious...
This $234,000 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research at Oregon Health & Science University to investigate immunometabolic dysregulations in the offspring of obese mothers. The research aims to determine if increased inflammation in high-fat diet-fed pregnant mice causes early-life immunometabolic reprogramming in their offspring, leading to metabolic...
This Project Grant award from the National Institutes of Health's (NIH) Child Health and Human Development Extramural Research program (CFDA 93.865) provides $234,000.00 to the University of Colorado-Denver to investigate the role of a novel NF-kB genetic variant in the development of preeclampsia, a serious vascular disorder during pregnancy. The research aims to establish whether this genetic variant is associated with impaired placental development, elevated inflammatory cytokines, reduced...
This Project Grant award of $225,528.00 from the National Institute of Child Health and Human Development (NICHD), authorized under CFDA 93.865 - Child Health and Human Development Extramural Research, will support research at The Johns Hopkins University to investigate the impact of influenza A virus (IAV) infection on the maternal gut microbiome and its contribution to adverse fetal and perinatal outcomes. The research aims to characterize changes in intestinal morphology, microbial...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $915,924 to Childrens Hospital Medical Center in Cincinnati, Ohio to investigate how disruptions in the infant lung microbiome affect the development and function of lung immune cells and epithelial cells. The overarching goal is to better understand how early-life dysbiosis (microbial imbalance) leads to long-term lung health...
This federal Project Grant award of $249,000 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of methodologies to reveal the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The research aims to develop a computational pipeline for reduced metagenomic sequencing to profile the blood microbiome, and a deep learning framework to optimize diagnosis and prediction models...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $193,582.00 to The Washington University in St. Louis to model the effects of the gut microbiota of undernourished mothers with environmental enteric dysfunction on vascular remodeling at the fetal-placental interface. The key products and services delivered under this grant include: 1) Characterizing the effects of the gut...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the relationship between prenatal maternal sleep and the development of cardiometabolic risk in offspring. The $696,470 grant will be used to: Examine how prenatal maternal sleep trajectories predict maternal biological pathways, such as inflammation and cortisol levels, that may impact offspring cardiovascular disease risk. Determine how prenatal...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $639,151 to Augusta University Research Institute, Inc. to investigate sex differences in the gut microbiome, immune system, and their role in salt-sensitive hypertension and kidney disease. The research will be conducted using Dahl salt-sensitive rat models and human samples from an opposite-sex twin cohort. The key...