Project Grant R56HL169434
Award Date
9/24/24
Completion Date
8/31/25
Dollars Obligated
$639K
Federal Agency
National Heart Lung and Blood Institute
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Augusta, GA 30912, USA
Similar Awards
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on investigating the role of conjugated bile acids as potential antihypertensive metabolites. The $768,896 grant will be used to address two key questions: 1) why are conjugated bile acids depleted in hypertension, and 2) what is the mechanism by which conjugated bile acids, particularly taurocholic acid, provide protection against...
This $250,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research at Colorado State University to investigate the role of maternal gut microbiome and inflammation in preeclampsia and subsequent cardiometabolic disease in offspring. The key research aims are to: 1) Determine if the maternal gut microbiome contributes to pro- or anti-inflammatory short-chain fatty acid signaling at the...
This Project Grant award, totaling $616,521, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Baylor College of Medicine in Houston, TX. The award will fund research to investigate the role of bacterial extracellular vesicles (EVs) as mediators of the gut-brain axis and their contribution to the development of hypertension. The research aims to: 1) identify the bacterial origin of EVs involved in hypertension and examine the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a translational research study to investigate the role of the gut microbiome in the development of acute kidney injury (AKI) associated with sepsis. The $126,846 award to the Regents of the University of Michigan will fund two key objectives: 1) identifying gut bacteria in human sepsis patients that...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support the development of methodologies to reveal the role of the blood microbiome in the gut-lung axis for asthma pathogenesis. The $249,000 award to Brigham & Women's Hospital will fund a 3-year research project to create a strain-resolved computational pipeline for reduced metagenomic sequencing to profile the blood microbiome, and develop a deep learning...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) totaling $2,594,544 provides funding to the Beckman Research Institute of the City of Hope to conduct research on the role of mucin-degrading intestinal bacteria in complications associated with hematopoietic cell transplantation (HCT). The research will investigate how Akkermansia and Bacteroides bacteria that can utilize intestinal mucus...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate the molecular mechanisms by which high salt intake regulates the sodium-potassium-chloride co-transporter (NKCC2) in the thick ascending limb of the kidney, and to identify novel E3 ubiquitin ligases that mediate NKCC2 ubiquitination and play a role in salt-sensitive hypertension. The...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to uncover the prevalence and biological roles of protein arginylation, a critical post-translational modification, in cardiovascular development and disease. The $633,720 award, effective January 25, 2025 through November 30, 2028, aims to: 1) establish a chemical proteomics platform to comprehensively profile arginylation sites in cardiac cell and...
This Project Grant award of $462,000.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate how the human microbiome influences the immune response and survival outcomes in sepsis. The key objectives are to: Elucidate the underlying mechanisms by which the microbiome primes and regulates neutrophil function in healthy individuals. Determine the effects of microbiome-mediated neutrophil priming on...
The federal Project Grant award R15DK136098, "SEX DIFFERENCES IN HEDONIC FEEDING: THE ROLE OF THE GUT MICROBIOME," is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $416,456 award to Furman University aims to characterize sex differences in the gut microbiome and their impact on hedonic feeding, or food intake driven by pleasure rather than...