This federal Project Grant award of $757,157, provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development of complementary experimental and computational strategies for high-throughput characterization of the impact of genetic variants on key regulatory and DNA repair genes. The award will fund the creation of SCBE-SEQ, a technology that combines pooled genome editing with single-cell sequencing to...
The National Human Genome Research Institute (NHGRI) awarded a $1,350,896 Project Grant (CFDA 93.172 - Human Genome Research) to the University of California, San Diego to develop novel technology for studying how regulatory DNA sequences control gene transcription. The goal is to create a "multimodal MPRA platform" that can simultaneously measure the effects of regulatory sequence perturbations on chromatin state, protein-DNA interactions, 3D chromatin interactions, and...
The National Human Genome Research Institute (NHGRI) awarded a $993,446 Project Grant under the Human Genome Research program (CFDA 93.172) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, which runs from May 1, 2025 to April 30, 2030, supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical co-operative...
This $1,205,737.49 federal Project Grant award was made on September 10, 2024 by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172). The grant will support the development of scalable computational methods and software tools to enable more effective analysis and interpretation of large genomic datasets for biomedical research. Key objectives include: Improving the computational efficiency of maximum likelihood estimation methods for...
This federal Project Grant award of $1,273,296 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) will support research to develop predictive models for the impact of genetic variations on mRNA stability and translation. The key products and services to be delivered under this grant include: Conducting high-throughput reporter assays to characterize how genetic variants in coding and untranslated regions impact mRNA stability and translation, including...
This $639,134 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) will fund the development of new methods for globally identifying protein and ribonucleoprotein (RNP) interactions with nascent, unspliced RNA in human cells. The key products to be delivered under this 4-year award include comprehensive binding site maps for several critical molecules involved in the splicing process, including RBFOX/LASR, U1 snRNP, and U2AF. This mapping...
This federal Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $457,920 to fund the development of a novel deep reinforcement learning framework for haplotype assembly. The Broad Institute, Inc. will conduct this research project to accurately partition DNA read fragments into two haplotype sets, leveraging publicly available datasets such as the 1000 Genomes Project. This approach aims to advance genome...
This $400,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under CFDA 93.172 "Human Genome Research" will support a research program at Brigham & Women's Hospital to develop advanced computational methods for accurately identifying and genotyping structural variants within large genetic biobank datasets. The key objectives of the work are to: 1) create haplotype-informed algorithms to improve detection sensitivity and genotyping accuracy for...
This $409,896 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of new statistical methods and analyses to leverage functional genomics data, in conjunction with genome-wide association study (GWAS) data, to better understand the functional effects of genetic variants and their roles in human diseases. The key objectives of this 5-year research program are to: (i) identify...
The federal Project Grant award under the Human Genome Research program (CFDA 93.172), administered by the National Human Genome Research Institute (NHGRI), provides $829,659 in funding from September 5, 2024 to June 30, 2028 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The award aims to develop methods for constructing queryable, multiscale, reference-free, and annotated 3D tissue atlases from 2D spatial genomics data. This will allow the...