Project Grant R01HD121468
- Federal Grant Award Summary Yale University received a $1.28 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion expected April 30, 2030. The project investigates the role of decidual extracellular vesicles (EVs) in mediating placental insufficiency, a pathological condition affecting 3–8% of pregnancies worldwide and...
- Federal Grant Award Summary Yale University received a $130,923 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded July 1, 2026, with completion targeted for June 30, 2028. The grant supports a postdoctoral research fellow in Yale's Department of Pediatrics to conduct immunological research examining enterovirus-reactive placental T cells as predictive biomarkers...
- Federal Project Grant Award Summary Yale University received a $1.93 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 25, 2025, with completion targeted for April 30, 2030. The award funds research investigating platelet dysfunction in pediatric multiple organ dysfunction syndrome (MODS), with specific focus on the role of endoplasmic reticulum...
- Federal Project Grant Award Summary Yale University received a $158,766 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through March 31, 2029. The award funds research to dissect the molecular mechanisms underlying endometriosis-related implantation defects and pregnancy complications through investigation of microRNA (miRNA) roles in...
- Federal Grant Award Summary Yale University received a $266,945 Project Grant from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective May 1, 2025 through April 30, 2030. The award funds the Yale Maternal, Newborn and Child Health Promotion (MNCHP) Training Program, a T32 institutional training initiative designed to develop the next generation of maternal, newborn, and child health...
- Federal Grant Award Summary Yale University received a $1.85 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 15, 2025, with completion expected by April 30, 2030. The award supports fundamental research into mechanisms regulating chromatin organization and epigenetic memory during early vertebrate development. The research investigates how the...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Massachusetts General Hospital a Project Grant totaling $1,503,452 under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the mechanistic intersection between placental vascular and newborn neuronal development in HIV-exposed but uninfected (HEU) children. The research project, initiated February 9, 2026 and scheduled for completion January 31,...
- Federal Project Grant Summary Yale University received a $698,032 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026, through April 30, 2031. The award funds research on centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging, with the primary deliverable being scientific research and analysis aimed at understanding...
- Federal Project Grant Award Summary Yale University received a $100,228 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective December 1, 2026, with completion targeted for June 30, 2029. The award funds fundamental research into tubulin post-translational modifications (PTMs) in female meiosis, addressing a significant gap in reproductive biology. The project...
- Federal Grant Award Summary Yale University received a $2.59 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded September 15, 2025, with completion targeted for August 31, 2027. The grant funds a prospective two-year clinical research study examining etonogestrel (ENG) contraceptive implant insertion at an alternative subdermal scapular site as a means to...
Grant Award Summary Yale University received a $2.53 million Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded July 1, 2026, with completion scheduled for May 31, 2030. The award funds research titled "PRIME: Placental Immune Response and Impact on Maternal-Infant Health," which investigates how antiretroviral therapy (ART) exposure during pregnancy affects immune development at the maternal-fetal interface. The project delivers mechanistic research outputs using immunopeptidomics, transcriptomics, and functional co-culture assays to elucidate how ART disrupts immune signaling, antigen presentation, and extracellular vesicle-mediated communication in the placenta. The research addresses immune dysregulation observed in HIV-exposed uninfected (HEU) infants, who experience elevated rates of preterm birth, growth restriction, and immune dysfunction. By generating detailed mechanistic insights into how in utero ART exposure reprograms the maternal-fetal immune environment, the award supports the development of safer therapeutic strategies during pregnancy and contributes to reducing long-term immune-mediated morbidity in this growing population. The work will be conducted at Yale University in New Haven, Connecticut.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 6/26/26 |