Project Grant R01HD120562
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $711,432 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to fund research on the molecular mechanisms of human meningomyelocele (spina bifida). The award supports recruitment and genetic analysis of family trios with narrowly defined inclusion and exclusion criteria, stratified by prenatal folic acid exposure, to investigate de...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $153,560 on December 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate gene regulatory mechanisms driving totipotency induction in human stem cells. The research examines how RNA splicing dysfunction alters early human development through integrative transcriptomic, epigenomic, and proteomic profiling. The work focuses on...
- The National Institute of Child Health and Human Development awarded the University of California, San Francisco $172,160 on December 17, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop lipid nanoparticle vectors for prenatal gene therapy treatment of Apert syndrome. The research uses induced pluripotent stem cells from patients with Apert syndrome to test whether RNAi and CRISPR/Cas9 nucleic acid constructs loaded onto lipid...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
- The National Institute of Child Health and Human Development awarded Massachusetts General Hospital $466,740 on August 3, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate congenital diaphragmatic hernia (CDH) using fetal tracheal aspirates as a molecular and cellular window into hypoplastic lung development. The project will examine when an inflammatory signature—characterized by increased cytokeratin 5 and activated NFKB expression with...
- The National Institute of Child Health and Human Development awarded University of California Irvine $233,528 on September 27, 2025, under the Child Health and Human Development Extramural Research (CFDA 93.865) program to support research on gene regulatory redundancy in mammalian development. The recipient will conduct experimental work to identify distinct transcription factors driving shadow enhancers—redundant non-coding DNA elements that control gene expression during development—and...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $500,000 on September 1, 2026, under the Child Health and Human Development Extramural Research grant program (CFDA 93.865) to conduct single-cell molecular characterization and computational drug discovery for fertility-sparing treatment of uterine fibroids. The project applies single-nucleus RNA sequencing and computational drug-repurposing methods to identify...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $123,147 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research investigating granulosa-derived RNAs as targets for oocyte rejuvenation and age-related oocyte quality infertility. The project comprises three aims: interrogating the mechanism by which RNAs transfer from granulosa cells to...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $352,600 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the interplay between the chromatin organizer SATB1 and the transcription factor PIT1 during postnatal maturation of the pituitary gland. The research addresses the molecular mechanisms underlying combined pituitary hormone deficiency caused by...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $716,738 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.HDR) for research on fibroblast growth factor (FGF) signaling in splenic development and the mechanisms underlying congenital asplenia. The award funds investigation of FGF-dependent cross talk between mesenchymal and mesothelial cells during spleen formation, using mouse models to identify transcription factor regulatory networks and signaling pathways that control splenic anlage development. The research addresses isolated congenital asplenia (ICA), a rare birth defect in which the spleen fails to develop, resulting in susceptibility to life-threatening infections in affected newborns and children. The project runs through May 31, 2031, with performance at the University of California, San Francisco in San Francisco, California. This is a project grant, the standard assistance vehicle for investigator-initiated research under the NICHD extramural portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $716.7k | 9/3/26 |