Project Grant R01HD120404
- The National Institute of Child Health and Human Development awarded The Trustees of the University of Pennsylvania $704,336 on August 17, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of T cells in transgenerational epigenetic inheritance. The funded research examines how the immune system, specifically T cells, can epigenetically alter phenotypes across multiple generations of progeny. Preliminary data demonstrates that T...
- The National Institute of Child Health and Human Development awarded $149,190 to The Trustees of The University of Pennsylvania on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to determine the postfertilization regulatory functions of a sperm microRNA cluster. The research investigates how sperm microRNAs influence early embryonic development and mediate the paternal transmission of non-genetically inherited phenotypes. The project...
- The National Institute of Child Health and Human Development awarded the University of Pennsylvania $100,228 on January 1, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate long-lived cardiac myosins as regulators of oocyte cytoskeletal integrity and reproductive lifespan. The research examines how exceptionally long-lived proteins—specifically A- and B-cardiac myosin heavy chain proteins (MHC-A/-B)—maintain oocyte cytoskeletal...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded The Trustees of The University of Pennsylvania $149,190 on January 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to elucidate the biochemical mechanisms of SCMH1, an accessory subunit of polycomb repressive complex 1, during cellular differentiation. The research investigates SCMH1's role in polycomb-mediated gene repression through RNA-binding and nuclear condensation....
- The National Institute of Child Health and Human Development awarded Duke University $581,258 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transposable elements as mechano-response enhancer elements regulating human embryonic stem cell fate. The research examines how mechanical forces regulate transposable element sequences that control gene expression and pluripotent stem cell differentiation. The project tests three...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $635,308 on August 24, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to investigate the long-term epigenetic consequences of DNA damage during embryonic development. The research examines how double-strand DNA breaks during gastrulation and organogenesis trigger genome integrity pathways that establish long-term silencing...
- The National Institute of Child Health and Human Development (NICHD) awarded The Trustees of The University of Pennsylvania $219,304 on February 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role and regulation of the IC2 imprinted gene cluster in extravillous trophoblast (EVT) differentiation during human placental development. The research establishes the functional mechanisms by which IC2-regulated genes—specifically...
The National Institute of Child Health and Human Development awarded The Trustees of the University of Pennsylvania $600,000 on August 15, 2026, for Project Grant R01HD120404 under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds investigation of how DNA repeat evolution—transposable elements, telomeric satellites, and centromeric satellites—affects early mammalian embryonic development and genome function. The research uses mouse models to test how species-specific divergence in repetitive DNA between maternal and paternal genomes triggers early embryonic arrest in hybrid embryos. The work includes transcriptional and epigenomic profiling of early embryos to identify perturbations in interactions between paternal transposable elements and maternally provisioned proteins during zygotic genome activation. Three experimentally tractable mouse models enable investigation of how specialized zygotic chromatin renders the early embryo sensitive to DNA repeat sequence and copy number divergence. Performance occurs in Philadelphia, Pennsylvania. The period of performance runs through May 31, 2031. This is a project grant, the standard NIH investigator-initiated research assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $600.0k | 8/13/26 |