The University of Missouri System, doing business as the Curators of the University of Missouri, was awarded a $217,371 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund preclinical testing of early life anti-myostatin therapy for treating osteogenesis imperfecta (OI), a connective tissue disorder resulting in muscle weakness, bone deformity, and fragility. The research aims to evaluate the efficacy of pharmacologically inhibiting maternal and fetal myostatin, a negative regulator of muscle mass, during pregnancy, lactation, and early adulthood in two OI mouse models. Key outcome measures will assess improvements in musculoskeletal health, including skeletal muscle and bone mass and strength, for both wild-type and OI offspring. The project will provide critical preclinical data to support the development of innovative therapies for this debilitating genetic condition.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $217.4k | 7/27/23 |