Project Grant R56HD110848

Award Date 8/1/23
Completion Date 7/31/24
Dollars Obligated $217K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Columbia, MO 65211, USA
Similar Awards
This $420,883 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve muscle regeneration and restore function following serious traumatic injuries. The University of Missouri System, the prime recipient, will leverage its expertise in microvascular imaging, muscle biology, and biomaterials to investigate the role of fibroadipogenic...
The University of Missouri System (UMS) has been awarded a $532,902.00 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The grant, titled "TARGETING SHP2 TO IMPROVE OUTCOME OF DUCHENNE MUSCULAR DYSTROPHY-ASSOCIATED CARDIOMYOPATHY", is for the period of Sep 1, 2023 to Aug 31, 2025. Through this award, the UMS will conduct research to develop medical solutions to improve outcomes for individuals with Duchenne muscular...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to resolve the mechanism of osteoclast multinucleation and signaling in bone remodeling. The $249,000 award to the Rector & Visitors of the University of Virginia will fund a 3-year research project to: 1) identify the domain of the lupus La protein that regulates osteoclast...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $221,100 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Massachusetts Medical School to develop and evaluate in vivo gene editing strategies to repair collagen mutations in mouse models of osteogenesis imperfecta (OI). The 2-year project aims to use bone-targeting recombinant adeno-associated virus (rAAV) to implement precise gene editing...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,963,122 to the University of Missouri System to conduct fundamental research on the molecular mechanisms regulating uterine development. The research aims to improve understanding of genetic and epigenetic factors governing epithelial specification, differentiation, and morphogenesis in the...
This $312,747 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research conducted by the University of California, Los Angeles (UCLA) to investigate the genetic determinants of endoplasmic reticulum (ER) stress in osteogenesis imperfecta (OI) and its impact on cellular receptors. The key objectives are to establish the genotype-dependent nature of ER stress in OI and determine how...
The University of Missouri System was awarded a $357,666 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to conduct research on two genome maintenance systems: the human transcription factor IIH (TFIIH) and the type IA topoisomerase of Mycobacteria. The research aims to use a combination of single-molecule force and fluorescence measurements, as well as computational methods, to study the coordinated...
The National Institute of Child Health and Human Development (NICHD) awarded a $295,923 Project Grant to Biostrategies LC under the Child Health and Human Development Extramural Research program (CFDA 93.865). The purpose of the award is to develop a "delivery-enhanced" gene therapy drug comprising an RTB:GALNS fusion protein for treating the rare metabolic disorder Mucopolysaccharidosis Type IVA (Morquio A Syndrome). The key objectives are to: 1) optimize the RTB:GALNS construct for...
This $483,070 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" supports research into the dynamics of bone extracellular matrix (ECM) assembly and resorption. The study aims to investigate how osteogenic cellular dynamics, differentiation, and cell fate are integrated with collagen assembly and mineralization, as well as how osteoclast bone resorption...
The University of Missouri System was awarded a $423,027 Cooperative Agreement from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to establish the MU Rodent Testing Center for Somatic Cell Genome Editing. The center will provide comprehensive services and expertise to evaluate new genome editing tools and technologies using relevant preclinical rodent models, including both mice and rats. Key objectives include breeding...

The University of Missouri System, doing business as the Curators of the University of Missouri, was awarded a $217,371 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund preclinical testing of early life anti-myostatin therapy for treating osteogenesis imperfecta (OI), a connective tissue disorder resulting in muscle weakness, bone deformity, and fragility. The research aims to evaluate the efficacy of pharmacologically inhibiting maternal and fetal myostatin, a negative regulator of muscle mass, during pregnancy, lactation, and early adulthood in two OI mouse models. Key outcome measures will assess improvements in musculoskeletal health, including skeletal muscle and bone mass and strength, for both wild-type and OI offspring. The project will provide critical preclinical data to support the development of innovative therapies for this debilitating genetic condition.

Generated 7/16/24, 6:14 AM