This Project Grant award of $128,214.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate how parental CENP-A protein levels equalize during the first cell cycle of mammalian embryogenesis. The award aims to advance understanding of the molecular origins of acquired aneuploidy, which can occur during early embryonic cell...
The Regents of the University of Michigan was awarded a $141,288 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) by the National Institute of Child Health and Human Development (NICHD). The grant will support a 6-year Training Program in Organogenesis, providing a unique multidisciplinary training experience for 6 predoctoral trainees annually. The program aims to unite career development activities with interdisciplinary research on organ...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will provide $896,013 to the Regents of the University of Michigan over a 5-year period from September 2024 to August 2029. The funding will support research to define the origins and evolution of mammalian sex chromosome dosage compensation mechanisms, which equalize X-linked gene expression between XX females and XY males. The research aims...
This Project Grant award of $380,495.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the mechanisms and factors that promote aberrant DNA repair at meiotic double-strand breaks, which can lead to the formation of de novo structural variants in the germline. The research program at the Regents of the University of Michigan will address how closely spaced double-strand...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research provides $1,279,780.00 to Wayne State University to study the mechanisms of the MEIG1 complex in mammalian spermiogenesis and fertilization. The key objectives are to: Dissect the motor-based complex in the manchette and its role in sperm formation Establish an in vivo system to investigate protein...
The Regents of the University of Michigan was awarded a $2,010,598 Project Grant from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to investigate the association between persistent intergenerational disadvantage and disparities in diarrheal disease, acute respiratory infection, and healthcare utilization among children under five. The research project aims to: 1) estimate the link between persistent...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $156,000 to the Regents of the University of Michigan from August 1, 2024 to July 31, 2026 to enhance and archive genomic data from the Panel Study of Income Dynamics (PSID) Child Development Supplement. The key products and services to be delivered under this award include: 1) Developing essential...
The National Human Genome Research Institute (NHGRI) awarded a $119,611 Project Grant under the Human Genome Research program (CFDA 93.172) to the Regents of the University of Michigan. The award period runs from August 29, 2024 to August 31, 2026. The grant will fund research to uncover regulatory networks controlled by transcription factors associated with monogenic diseases and decipher their involvement in driving complex disease phenotypes. The project aims to use advanced genomic...
The Regents of the University of Michigan received a $312,000.00 Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The 2-year grant, awarded on February 1, 2024, supports research to investigate "An Unexpected Role for the Ubiquitin Proteasome System in Repeat Associated Non-AUG Translation." This basic and translational biomedical research aims to advance understanding and treatment of neurological disorders...
This Project Grant award, valued at $423,036.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to better understand the molecular mechanisms underlying the biogenesis and function of pachytene piRNAs, a unique class of small RNAs found in mammalian germ cells. The research aims to elucidate how regulatory motifs direct piwi proteins to engage in piRNA biogenesis,...