Project Grant R01HD119283
- This Project Grant award, valued at $2,050,000.00 and funded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training, supports research to decipher the sexually dimorphic neural substrates governing aggression in female Drosophila melanogaster (fruit flies). The research aims to elucidate the neural mechanisms encoding sex-specific primal behaviors, investigate the modulatory effects of stress and peptides on female aggression,...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $529,878 to Boston Children's Hospital from December 1, 2024 to November 30, 2029. The project aims to investigate the molecular mechanisms underlying the desensitization of dopamine receptors that occurs after goal-directed behaviors, such as mating in Drosophila. This...
- This federal Project Grant award of $624,809.00, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Program (CFDA 93.865), supports research on the dopaminergic regulation of KNDY neurons and its implications for GnRH pulses and polycystic ovary syndrome (PCOS). The project, led by Brigham & Women's Hospital Inc. and involving the larger Partners Healthcare System (now Mass...
- This $162,512 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to examine how the circadian clock influences reproductive behavior and sexual drive in mice. The project, conducted by the Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA, aims to determine if the timing of peak sexual behavior between males and females impacts...
- This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the mechanism of pluripotency transitions during peri-implantation development. The $760,617 award to The Children's Hospital Corporation, doing business as Boston Children's Hospital, aims to address the technical challenges in working with limited...
- This federal Project Grant award of $752,491 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to understand the neural circuits mediating pulsatile and surge GnRH secretion in female mammals. The primary focus is on investigating the role of arcuate nucleus (ARN) neurons, including KNDY and KISS1R subpopulations, in driving episodic LH secretion and the LH surge....
- This federal Project Grant award of $787,154 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award was granted to The Children's Hospital Corporation, doing business as Boston Children's Hospital, to conduct a sequential mixed methods study examining the experiences of sexual orientation-based stigma among bisexual adolescents and young adults,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research...
- This $448,441 federal Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Emory University to investigate the role of mediobasal hypothalamic gliosis in gestational weight gain and visceral fat accretion. The primary aim is to provide foundational data on a potential neural mechanism underlying dysregulated or pathological weight gain during...
- This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants aims to investigate the developmental origins of mental illness by studying the structure and function of the human hypothalamus. The $392,500 award, effective January 1, 2025 through December 31, 2029, will capitalize on large-scale datasets from the Adolescent Brain Cognitive Development (ABCD) and Healthy Brain and Child Development (HBCD) studies to: 1)...
The federal Project Grant titled "NEUROENDOCRINE COMPUTATIONS UNDERLYING AN ENDURING BEHAVIORAL STATE" was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $571,485 award, with a performance period from August 2025 to June 2030, will support research by The Children's Hospital Corporation (doing business as Boston Children's Hospital) to investigate the computational mechanisms underlying neuroendocrine signaling and its role in stress-induced changes in behavior, such as the suppression of ovulation in Drosophila. The project aims to use the genetic tools available in Drosophila to precisely examine the molecular and electrical mechanisms that measure stress levels and determine the extent and duration of the neuroendocrine response. The research is expected to provide valuable insights into the interindividual differences in susceptibilities to stress and related disease states in humans.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $571.5k | 8/13/25 |