Project Grant R01HD117930
- The federal Project Grant award of $429,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to characterize placental extracellular vesicles (EVs) throughout human pregnancy. The goal is to develop novel methods to image, count, isolate, and validate placental cell- and size-specific EVs from maternal blood, in order to monitor placental...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
- This $429,000 federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the gene and environmental influences on placental angiogenesis and severe fetal growth restriction. The University of Colorado-Denver, the awardee organization, will leverage induced pluripotent stem cell technology to better...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $2,255,352 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, effective September 15, 2025 through May 31, 2028, will fund research to determine the cellular and molecular mechanisms involved in the transfer of inflammatory signals across...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of TLR7/8-activating microRNAs in driving fetal inflammatory response syndrome and preterm birth. The $132,779 award to Yale University aims to determine if fetal membrane/amniotic fluid-derived exosomes containing these microRNAs mediate...
- This federal Project Grant award of $452,000.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research conducted by the University of California, San Diego (UC San Diego) to identify a cellular immune signature unique to clinically-significant villitis of unknown etiology (VUE). VUE is a placental inflammatory lesion associated with late-onset fetal...
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
- This Project Grant award of $249,000 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Connecticut Health Center (UCHC). The funding will support a 3-year research project to study the transcriptional regulation and intercellular signaling at the maternal-fetal interface, with the goal of developing a prognostic model to relate individual...
- The University of California, San Diego (UCSD) received a $151,040 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, awarded on January 25, 2026, with a completion date of July 31, 2027, supports research to investigate the effects of rare damaging mutations in TGFβ latent complex proteins found in preeclamptic placentas. The key...
This federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research on the role of decidual extracellular vesicles in mediating placental insufficiency. The $654,671 award, which commenced on August 1, 2025 and is scheduled for completion by April 30, 2030, is being conducted by the awardee, Yale University. The key research objectives are to examine how uterine inflammation alters the miRNA cargo of decidual extracellular vesicles, and how this in turn impacts trophoblast stem cell differentiation and uterine vascular dysfunction, leading to placental insufficiency. This research aims to provide insights into the pathophysiology of fetal growth restriction and preeclampsia, which each affect 3-8% of pregnancies worldwide and have significant lifelong implications for mothers and their children.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $654.7k | 7/31/25 |