Project Grant R01HD115810
Award Date
8/16/24
Completion Date
5/31/29
Dollars Obligated
$628K
Federal Agency
National Institute of Child Health and Human Development
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Newark, NJ 07107, USA
Similar Awards
This $148,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund a study at the University of Southern Mississippi (USM) to investigate the potential molecular link between cancer and female infertility.
Specifically, the research project aims to (1) use humanized yeast to assess the impact of 30 cancer-associated polymorphisms in the protein phosphatase...
This federal Project Grant award, valued at $936,746 and funded by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports research at Rutgers, The State University of New Jersey to investigate the role of mitochondrial stress responses in ovarian cancer and their impact on antitumor immunity. The project aims to characterize the biology of the BTLP3A gene and how its dysfunction promotes accumulation of damaged mitochondria, triggering...
This $1,372,184 federal Project Grant award from the U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) supports research on the use of gonadotropin-releasing hormone analogs to protect ovarian reserve in adolescents and young adults with cancer. The primary awardee, Fred Hutchinson Cancer Center, will oversee the overall study design, data analysis, and project administration. Sub-awards were made to The Cleveland Clinic Foundation to contribute...
This Project Grant award, with an award amount of $593,617, was provided by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395). The grant aims to identify novel biomarkers and therapeutic strategies to address chemotherapy-induced cognitive impairment (CICI) in pediatric cancer patients. Key objectives include:
Evaluating if the PARP1 inhibitor Veliparib can prevent methotrexate-induced cognitive impairment in mouse models of pediatric T-cell acute...
This federal Project Grant award, identified as R21HD110932, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, totaling $232,500.00, supports research investigating the role of circular RNA (circRNA) in ovarian follicular development and fertility.
The research project aims to examine the effect of knocking out the KHDRBS1 gene, a regulator of circRNA...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $133,207 to Rutgers, The State University to conduct research on the molecular mechanisms underlying fertilization and egg activation.
The key objectives of this 2-year award are to: 1) investigate the function of the PGM-3 gene in the oocyte, 2) explore the effects of a newly identified...
This $241,944 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research on improving treatments for high grade serous ovarian cancer (HGSOC). The primary investigators are studying the efficacy and mechanism of action of two natural product compounds, didesmethylrocaglamide (DDR) and phyllanthusmin34 (PHY34), as a combinatorial therapy for HGSOC models. DDR inhibits mRNA translation while...
This federal Project Grant award, valued at $1,026,038.00, was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research to define the molecular mechanisms by which telomeric DNA is extended during preimplantation embryogenesis, including in a clinically relevant nonhuman primate model. The project aims to establish new concepts around the developmental...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $309,251 to Expanse Bio LLC to develop an ex vivo microfluidic organ perfusion device for long-term culture and assessment of whole ovaries. The goal is to create a more physiologically relevant model for evaluating the ovotoxicity (ovarian damage) potential of drug candidates, particularly...
This R01 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program provides $337,856 over a five-year period from August 2024 to May 2029 to study the role of leukocyte-derived cytokines in facilitating ovulation and luteinization in the human ovary.
The key products and services to be delivered through this award include:
Comprehensive characterization of the expression...