Project Grant R01HD115637

Award Date 8/5/24
Completion Date 4/30/29
Dollars Obligated $1.5M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
St. Louis, MO 63110, USA
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This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $253,066 to The Washington University in St. Louis to conduct research on the impact of induced labor with oxytocin on the developing oxytocinergic system and neurobehavioral outcomes in offspring. The key objectives are to: 1) Comprehensively map the developmental trajectory of oxytocin receptor expression in the...
This Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development and evaluation of a bioengineered 3D human myometrium model. The goal is to quantify the contractility of this in vitro model in response to varying doses of oxytocin, a key drug used to induce uterine contractions during labor. The $235,803 award, effective from April 1, 2025 to...
The National Institute of Child Health and Human Development (NICHD) awarded a $624,998 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Giner Inc., a small business in Auburndale, Massachusetts. The grant will support the development and validation of an electrochemical assay and point-of-care (POC) instrument for highly sensitive and rapid measurement of oxytocin levels. Oxytocin is a critical hormone involved in childbirth, postpartum...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), part of the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $170,420.00 to New York University School of Medicine to conduct research on improving clinical decision-making for high-risk pregnant patients with hypertensive disorders. The key objectives of the research are to: 1) Compare maternal health outcomes between patients with hypertensive...
The National Institute of Child Health and Human Development (NICHD) awarded a $427,625 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Washington University in St. Louis, Missouri. The grant aims to provide a mechanistic understanding of how maternal obesity affects uterine contractility and energy metabolism during labor and parturition. The researchers will use a mouse model of diet-induced obesity to investigate the impacts of excess fatty acids...
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This Project Grant award of $248,999 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to identify effective therapeutic agents for managing infection-induced preterm labor (III-PTL) and protecting against fetal inflammation. The key activities under this award include: 1) Optimizing a high-throughput screening assay to measure changes in pro-inflammatory cytokines...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), funds the development and validation of a machine learning-based fetal monitoring system to predict and prevent fetal hypoxia. The $261,310 award will support the creation of a high-sensitivity, high-specificity predictive model using a multi-site dataset of 50,000 fetal monitoring tracings coupled with...
This Project Grant award, totaling $769,842, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the utility of human milk oligosaccharides (HMOs) in inhibiting the perinatal pathogen, Group B Streptococcus (GBS), which can lead to adverse pregnancy outcomes like preterm birth and neonatal sepsis. The research will test the effects of HMOs on...
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This federal Project Grant award, valued at $1,526,336.00 and awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research program, supports a clinical and translational research study on optimizing the use of oxytocin for labor induction. The research aims to develop a better understanding of how pregnant patients physiologically and functionally respond to exogenous oxytocin administration, with the goal of improving labor induction success and reducing maternal and fetal morbidity. The key products or services to be delivered under this award include: 1) a prospective cohort study of 605 patients undergoing labor induction to develop a prediction model for labor progression using advanced contraction measures, 2) correlation of maternal serum oxytocin concentrations with contraction parameters in a subset of 84 patients, and 3) assessment of myometrial oxytocin receptor function, expression, and localization in relation to oxytocin dosage and duration. The research will be conducted by The Washington University, a prominent private research institution located in St. Louis, Missouri.

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