This Project Grant award, totaling $769,842, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to investigate the utility of human milk oligosaccharides (HMOs) in inhibiting the perinatal pathogen, Group B Streptococcus (GBS), which can lead to adverse pregnancy outcomes like preterm birth and neonatal sepsis. The research will test the effects of HMOs on GBS biofilm formation, colonization, and infection in various in vitro and in vivo models, including primary human placental macrophages, organ-on-a-chip systems, ex vivo gestational membranes, and a mouse model of pregnancy infection. This work could establish HMOs as a cost-effective dietary or chemotherapeutic strategy to improve pregnancy outcomes, particularly in vulnerable populations. Two sub-awards, totaling $129,642 and $128,623, were made to Louisiana State University and Vanderbilt University, respectively, to support specialized aspects of the research.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 10/30/24 | ||
| Not listed | $384.9k | 9/20/24 | ||
| Not listed | $384.9k | 9/20/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
129642S | Louisiana State University | Project Grant R01HD113675 | $14.8k | 12/26/24 | |
128623S | Vanderbilt University | Project Grant R01HD113675 | $75.7k | 12/16/24 |