Project Grant R01HD115550
- This Project Grant award of $148,880 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the long-term effects of preeclampsia (PE) on offspring. The research aims to isolate B cells from the placentas of PE patients and transfer them into pregnant rats to examine the impact on blood pressure, immune cells, cerebrovascular function, and cognitive...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- This $760,950 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Program (CFDA 93.865). The grant supports research at the University of Michigan to characterize how antibody fragments can modulate the signaling of G-protein coupled receptors (GPCRs), such as the oxytocin receptor and angiotensin II type I receptor, which are important in maternal and fetal health during pregnancy. The...
- This Project Grant award of $226,608.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is funding research to identify the mechanistic link between fetal glucagon and placental nutrient delivery. The goal is to establish how fetal glucagon regulates placental lactogen secretion and uterine blood flow as an adaptive mechanism for matching nutrient supply to...
- The federal Project Grant award of $429,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to characterize placental extracellular vesicles (EVs) throughout human pregnancy. The goal is to develop novel methods to image, count, isolate, and validate placental cell- and size-specific EVs from maternal blood, in order to monitor placental...
- This $448,441 federal Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Emory University to investigate the role of mediobasal hypothalamic gliosis in gestational weight gain and visceral fat accretion. The primary aim is to provide foundational data on a potential neural mechanism underlying dysregulated or pathological weight gain during...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
- This $429,000 federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the gene and environmental influences on placental angiogenesis and severe fetal growth restriction. The University of Colorado-Denver, the awardee organization, will leverage induced pluripotent stem cell technology to better...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate how amniotic fluid pressure and composition affect branching morphogenesis across organs during embryonic development. The $156,104 award, with a performance period from January 1, 2026 to July 31, 2028, will fund quantitative imaging analysis to compare...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health National Institute of Child Health and Human Development provides $769,916 to Emergent Biotechnologies LLC for research into a novel therapy for preeclampsia. The funding supports Phase 1 of developing and characterizing a handle region peptide as an innovative treatment for preeclampsia under the Child Health and Human Development Extramural Research program (CFDA 93.865). Phase 1 work will...
This federal Project Grant award of $648,102 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Program (CFDA 93.865) aims to investigate the role of the GPR173 receptor and the associated phoenixin peptide in regulating plasma volume expansion during pregnancy. The research team at Saint Louis University will use siRNA-mediated knockdown techniques in pregnant rats to evaluate the impact of disrupting hypothalamic PNX/GPR173 signaling on water drinking behavior, arginine vasopressin secretion, and fetal growth. The project seeks to elucidate the central mechanisms underlying pregnancy-associated plasma volume expansion, which is critical for proper placental perfusion and fetal development. The award has a project period from September 1, 2025 through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $648.1k | 8/29/25 |