Project Grant R01HD113747

Award Date 8/15/24
Completion Date 4/30/29
Dollars Obligated $1.2M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Pullman, WA 99164, USA
Similar Awards
This Project Grant award, valued at $107,458.00 and issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research conducted by Duke University to investigate the mechanisms of double-strand break repair in fetal male germ cells. The central objective is to determine how male germ cells in the G0 quiescent phase respond to and repair double-strand DNA breaks, and to elucidate...
This Project Grant award of $271,728 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by the Whitehead Institute for Biomedical Research to uncover the molecular mechanisms that initiate and maintain germ cell identity. The key objectives of the research are to: (a) discover mechanisms that repress somatic programs and allow the primordial germ cell (PGC) program to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $658,633 to Wayne State University to conduct research on the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo for sperm tail formation and in remodeling chromatin during...
This Project Grant award, with a total funding amount of $157,000.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to reveal how the protein ASZ1 recruits PIWI proteins to a cellular structure called intermitochondrial cement (IMC) to facilitate the biogenesis of PIWI-interacting RNAs (piRNAs). This is a critical process for maintaining genomic...
This $380,546 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to define how post-transcriptional regulation of gene expression shapes the function of spermatogonial stem and progenitor cells in the mouse model. The key objectives are to: 1) Investigate how the RNA-binding protein DAZL enhances retinoic acid-mediated transcriptional and translational changes to induce...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $248,999.00 to Colorado State University to investigate the mechanisms behind temperature-sensitive meiotic chromosome structures in male infertility. The project aims to: 1) Determine how differences in the organization and composition of the synaptonemal complex (SC) during spermatogenesis render...
The federal Project Grant award R01HD112533, in the amount of $1,407,333.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research at the Albert Einstein College of Medicine to investigate the role of the Rho kinase (ROK) protein and its substrate Combover (CMB) in the male germline of Drosophila, with a focus on understanding their function in...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program provides $148,000 in funding to the University of Southern Mississippi to investigate the potential molecular mechanisms linking infertility and cancer. The primary objectives are to (1) use humanized yeast to assess the impact of 30 cancer-associated protein phosphatase 1 (PP1) variants on cell growth and...
This federal Project Grant award for $1,713,959, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research on the structure and remodeling of sperm chromatin during spermiogenesis and fertilization in the fruit fly (Drosophila melanogaster) model organism. The key objectives of this research project are to: 1) perform biochemical, biophysical, and structural analyses...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research investigating the relationship between genome mutagenesis, fertility, and health in fertile and infertile men. The $245,619 award to the University of Utah will fund a 2-year research project with the following key objectives: Examine germline mutation rates from the bulk sperm of...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research by Washington State University (WSU) to investigate how the RUNX family of transcription factors balance cell fate and function in the male germline during prepubertal development.

The $1,216,126 award, spanning from August 2024 to April 2029, aims to elucidate the mechanisms by which RUNX1 and RUNX3 regulate the balance between germ cell proliferation/self-renewal and differentiation. The research will leverage single-cell 'omics approaches to functionally evaluate the roles of these RUNX factors and explore their lineage-tracing through developmental stages. Findings from this work are expected to contribute fundamental knowledge about how tissue-specific stem cells balance fate and function, with potential implications for understanding and addressing infertility with developmental origins.

Generated 6/17/25, 1:48 AM