This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $178,068 to support Dr. Susanna Mitro's research over a four-year period from March 2025 to February 2029. The proposed research aims to elucidate the complex interrelationships between cardiovascular health and benign gynecologic disease, specifically uterine fibroids, using electronic health record data from Kaiser Permanente Northern California. The key objectives are to: 1) quantify prospective associations between blood pressure trajectories/hypertension and fibroid diagnosis; 2) estimate the causal effect of angiotensin-converting enzyme inhibitor versus thiazide diuretic treatment on fibroid diagnosis; and 3) develop and validate a clinical fibroid severity model. This research has the potential to expand understanding of fibroid etiology and lead to new treatment or prevention strategies. The award also supports Dr. Mitro's career development through mentored training in pharmacoepidemiology, women's cardiovascular epidemiology, and other professional skills.