This Project Grant award of $2,344,039 from the National Institute of Child Health and Human Development (NICHD, CFDA 93.865 Child Health and Human Development Extramural Research) aims to identify factors contributing to the racial disparity in uterine fibroid incidence between Black and White women. The key products and services to be delivered include: Analyzing data from the Black Women's Health Study and Nurses' Health Study II cohorts to determine if established fibroid risk factors...
This Project Grant award of $2,121,229 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to evaluate the impact of altered gene expression on uterine fibroid risk in African ancestry populations. The key products and services to be delivered include: Testing for the association of known and novel fibroid genome-wide association study (GWAS) loci among Nigerian women...
This Project Grant award of $461,320 from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) supports a study on risk factors and consequences of endometriosis among Black women. The award recipient, the Fred Hutchinson Cancer Center, will leverage data from the Black Women's Health Study to evaluate whether established endometriosis risk factors are associated with endometriosis risk in Black women...
This Project Grant award of $149,000 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research (CFDA 93.865) program aims to examine the impact of longitudinal patterns of adverse childhood experiences (ACEs) on adolescent sexual and reproductive health. The research will utilize innovative analytic methods applied to longitudinal data from the Fragile Families and Child Wellbeing Study to: 1) uncover patterns of...
This Project Grant award of $2,567,596 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund a longitudinal study on the impacts of adverse childhood experiences (ACEs) on the health, partnerships, and parenting of young adults in Malawi, a low-income country. The study has four key aims: 1) estimating the longitudinal impacts of ACEs on sexual, reproductive, and mental health...
This federal Project Grant award in the amount of $268,065 was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research to assess the association between childhood sexual abuse (CSA) and increased risk of debilitating gynecologic conditions such as uterine leiomyomata, endometriosis, and polycystic ovarian syndrome. The research will leverage the existing...
The National Institute of Child Health and Human Development (NICHD) awarded a $427,625 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of North Carolina at Chapel Hill on August 7, 2024. The grant will fund a secondary data analysis study exploring the mechanisms linking maternal childhood adversity to adolescent psychopathology, with a focus on the roles of early childhood deprivation and threat. The study will leverage a rich longitudinal...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $176,255 to the University of Nevada, Reno to conduct research on the social contextual factors contributing to racial inequities in maternal and infant health outcomes. The study aims to uncover how adolescent social developmental contexts shape biological and social stress pathways that impact maternal health and birth...
The National Institute of Child Health and Human Development (NICHD) awarded a $251,310 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Johns Hopkins University to examine the impacts of child sexual abuse (CSA) on women's impaired fecundity, pregnancy outcomes, and preterm delivery. The study aims to: 1) estimate the impact of CSA on women's reproductive health outcomes; 2) identify patterns of child abuse and their association with reproductive...
This $107,860 Project Grant, awarded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to understand the functional role of fibroid subtype mutations in developing new targeted therapies for uterine fibroids. The research aims to 1) determine the functional roles of HMGA2 over-expression and MED12 mutation in uterine fibroids, 2) predict and test drug compounds to target...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $229,393 to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on the relationship between early life adversities and the risk of uterine fibroids among Black/African American women.
The key products and services to be delivered include: 1) describing the prevalence and characteristics of adverse childhood events (ACEs) occurring before age 12 and their association with childhood and adult contextual factors; 2) examining the relationship between ACEs and trajectories of C-reactive protein; and 3) evaluating the association between ACEs and the incidence and growth of uterine fibroids, as well as the potential modifying effect of psychosocial resources. This research aims to elucidate the role of early life stress as a risk factor for uterine fibroids, which disproportionately impact Black/African American women, and provide insights to improve quality of life and reduce related health disparities.