This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $378,123 to the Research Foundation of the City University of New York (RFCUNY) to identify and test mechanisms that establish the transcriptional regulatory potency of early embryos. The project aims to investigate the relationships among DNA accessibility, nucleosome lability, transcription,...
This Project Grant award, with a total funding of $1,887,823, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research focused on understanding the regulation of trophoblast cell development, which is critical for successful pregnancy establishment. The key objectives are to investigate the roles of the activin-follistatin like 3 and Wnt-Wnt antagonist...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $148,000.00 to The University of Southern Mississippi to conduct a pilot study on the molecular link between cancer and oocyte-based infertility. The key objectives of this 2-year project are to: (1) investigate the potential molecular mechanisms connecting infertility and cancer, with a focus on the...
This Project Grant award for $1,080,375.00 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research at the University of Massachusetts Medical School (UMass Medical) to investigate the role of maternal transcripts and RNA-binding proteins in reproductive fecundity using the nematode Caenorhabditis elegans as a model organism. The research aims to...
The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $107,458 to Duke University to investigate the mechanisms of double-strand break repair in fetal male germ cells. The research aims to determine how male germ cells in the G0 phase repair DNA double-strand breaks and elucidate the importance of this process for spermatogonial stem cell development. The...
This Project Grant award of $3,422,481.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to develop a comprehensive genomic resource to characterize novel causes of unexplained recurrent pregnancy loss (RPL). The key activities include leveraging large clinical data and biobank resources to classify molecular variations linked to RPL, utilizing a high-throughput...
This Project Grant award, valued at $1,454,109 and running from July 1, 2024 to April 30, 2029, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to investigate the physiological and genetic mechanisms underlying placental responses to hypoxia and their impact on fetal growth and development. The key research activities include: Generating cell...
This $147,486 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of the KIF2C protein in regulating the microtubule cytoskeleton during the oocyte-to-embryo transition in zebrafish. The research, conducted by The Trustees of the University of Pennsylvania, aims to determine how KIF2C modulates microtubule...
This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to investigate the molecular mechanisms underlying fertilization and egg activation in the Caenorhabditis elegans model system. The $133,207 award, which will span from August 2024 to July 2026, will enable the postdoctoral researcher to: Investigate the molecular function of...