Project Grant R01GM166117
- The National Institute of General Medical Sciences awarded the University of Florida $387,845 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a personalized sepsis-risk engine using explainable artificial intelligence and in vitro validation. The research integrates multimodal electronic health record data with high-dimensional omics and mechanistic modeling to identify host pathways that convert neutropenic infection into sepsis and...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $123,309 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for improving sepsis diagnosis through plasma metagenomic sequencing. The research addresses the challenge of timely and accurate sepsis diagnosis in critically ill patients by analyzing microbial and host cell-free DNA (cfDNA) in blood plasma. Current diagnostic...
- The National Institute of General Medical Sciences awarded the University of Florida $411,407 on August 15, 2026, to develop a bioanalytical platform for monitoring and modeling sepsis immunopathology under the Biomedical Research and Research Training program (CFDA 93.859). The funded research establishes an integrated platform to capture ultrasensitive, longitudinal biochemical monitoring of immune effectors in sepsis patients and develop dynamic disease models linking biochemical trends to...
- The National Institute of General Medical Sciences awarded Duke University $446,410 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, R01GM163225) to develop and validate statistical methods for identifying disease subtypes in patient populations, with application to sepsis. The project develops three classes of Bayesian statistical approaches designed to address limitations in standard clustering techniques: Bayesian multiview pyramids to handle...
- The National Institute of General Medical Sciences awarded The Washington University $777,500 on September 19, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms driving host-associated microbial community dynamics. The research examines how environmental and host physiological factors interact to shape gut microbial community development and variation across an individual's lifespan, with focus on understanding how normal variation in...
- The National Institute of General Medical Sciences awarded The Washington University $1.244 million on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop real-time software-hardware integration for dynamic control of tissue mechanical environments in high-throughput drug development systems. The recipient will integrate four key technologies: rapid algorithms for directly estimating contractility of excitable tissues, GPU-acceleration approaches...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $411,475 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to engineer a multiplexed biomaterial-based bioluminescent biosensor platform for real-time sepsis diagnosis and precision immunotherapy guidance. The recipient will develop a rapid ex vivo biosensor using biomaterial-immobilized complementation antibody pairs to dynamically sense proteomic...
- The National Institute of General Medical Sciences awarded The Washington University $410,520 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research uncovering the molecular principles of intracellular electrochemistry. The recipient will explore fundamental physicochemical and electrochemical features of living systems; establish theoretical frameworks to understand how electrochemical features such as proton motive force define passive...
- The National Institute of General Medical Sciences awarded The Washington University $200,613 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the role of proton-sensing G protein-coupled receptors in trauma and hemorrhagic shock. The research examines how trauma combined with hemorrhagic shock influences expression and activation of proton-sensing G protein-coupled receptors (GPR4 and GPR68) on cerebral endothelial cells, and whether...
- The National Heart, Lung, and Blood Institute awarded Worcester Polytechnic Institute $532,935 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of the endothelial glycocalyx in sepsis-induced coagulopathy. The research targets sepsis-associated coagulopathy, a condition characterized by uncontrolled thrombosis, large vessel occlusion, and stroke that resists traditional anticoagulation therapies. The project will examine how sepsis...
The National Institute of General Medical Sciences awarded The Washington University $359,227 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop graph neural networks and longitudinal mediation analysis methods for early detection of hospital-onset sepsis and identification of modifiable risk factors. The project investigates system-level hospital characteristics—including hospital organization, nursing workload, and healthcare personnel interactions—that influence hospital-onset sepsis incidence and outcomes, moving beyond patient-level risk factors that dominate existing research. The recipient will validate electronic health records data inputs for patients' exposure to healthcare personnel and nursing workload against direct observation, develop dynamic graph neural networks based on patient connections to improve prediction of time-to-hospital-onset sepsis, and employ longitudinal mediation analysis to uncover whether system-level features causally influence sepsis prevalence. Work is performed in St. Louis, Missouri with a period of performance through April 30, 2031. The research conceptualizes hospitals as dynamic spatiotemporal networks where individual patient risk is shaped not only by personal characteristics but also by physical location within the facility and exposure pathways through healthcare personnel and the hospital environment, with particular attention to nursing roles in device care and infection prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $359.2k | 8/18/26 |