Project Grant R35GM165480
- The National Institute of General Medical Sciences awarded Michigan Technological University $383,801 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop cost-effective, scalable biosensing platforms for rapid multiplex biomarker detection in sepsis, allergy, and other complex diseases. The research focuses on molecularly imprinted polymers (MIPs)—synthetic receptors that mimic antibody recognition with superior stability and lower production...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $100,228 on February 13, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop engineered cell-based systems that detect and treat sepsis through synthetic receptors targeting alarmin proteins S100A8 and S100A9. The project will explore two complementary cell engineering strategies: engineering cells to constitutively secrete therapeutics that modulate...
- The National Institute of General Medical Sciences awarded the University of Florida $411,407 on August 15, 2026, to develop a bioanalytical platform for monitoring and modeling sepsis immunopathology under the Biomedical Research and Research Training program (CFDA 93.859). The funded research establishes an integrated platform to capture ultrasensitive, longitudinal biochemical monitoring of immune effectors in sepsis patients and develop dynamic disease models linking biochemical trends to...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $123,309 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for improving sepsis diagnosis through plasma metagenomic sequencing. The research addresses the challenge of timely and accurate sepsis diagnosis in critically ill patients by analyzing microbial and host cell-free DNA (cfDNA) in blood plasma. Current diagnostic...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $426,539 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop AI-driven robotic systems that plan, execute, and interpret automated experiments mapping bacterial pathogen phenotypes and quorum sensing pathways. The work focuses on context-specific cellular networks in streptococci, integrating metabolism and quorum sensing into a quantitative...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the Regents of the University of Michigan $549,998 on February 15, 2026, under the Engineering program (CFDA 47.041) to develop ultrasensitive single-molecule protein detection technologies that simultaneously measure low-abundance proteins and their functional activities in biological samples. The project will establish a design framework to detect multiple low-abundance...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Regents of the University of Michigan $429,000 on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop an ultrasensitive bioassay platform based on microlaser ensemble quenching technology. The research addresses a core limitation in digital enzyme-linked immunosorbent assay (ELISA): while digital ELISA achieves high sensitivity by...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $516,410 on April 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop precision biomaterials that enrich and monitor antigen-specific immune cells in vivo. The research addresses a critical gap in immunological assessment: current methods for measuring antigen-specific cells require expensive and time-consuming ex vivo expansion that can alter cell...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $100,228 on October 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to engineer cell-based sensors for autoimmune disease detection and monitoring. The project, titled "Engineered Cell Sensors for Autoimmune Monitoring," develops synthetic cell receptors using Modular Extracellular Sensor Architecture (MESA) to detect interleukin-23 (IL-23), a...
- The National Institute of General Medical Sciences awarded $410,473 to the Regents of the University of Michigan on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop quantitative theory and computational models of collective cellular response to complex biophysical cues. The research encompasses two projects: investigation of swarming bacterial colonies' response to intestinal tissue cues in healthy and disease states, and analysis of...
The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $411,475 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to engineer a multiplexed biomaterial-based bioluminescent biosensor platform for real-time sepsis diagnosis and precision immunotherapy guidance. The recipient will develop a rapid ex vivo biosensor using biomaterial-immobilized complementation antibody pairs to dynamically sense proteomic activity and multiplexed cytokines from human serum. The platform will stratify sepsis by disease trajectory and etiology, and will generate a diagnostic tool to guide selection of immunomodulatory therapies in silico. The work builds on the laboratory's prior development of programmable biomaterials for immune modulation, valency-controlled protein presentation systems, oxygen biosensors, and antibody-based biomaterial sensors. The award addresses the challenge that cytokines are powerful early biomarkers of sepsis but their use remains confined to research and specialized laboratories due to complexity, and that artificial intelligence-based detection systems are not feasible in resource-limited healthcare settings. The long-term vision is a bedside-ready platform capable of continuous immune monitoring to provide actionable diagnostic insights. Work is performed at Ann Arbor, Michigan. The period of performance runs from September 1, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $411.5k | 8/12/26 |