Project Grant K99GM163014
- The National Institute of General Medical Sciences awarded the University of Florida $411,407 on August 15, 2026, to develop a bioanalytical platform for monitoring and modeling sepsis immunopathology under the Biomedical Research and Research Training program (CFDA 93.859). The funded research establishes an integrated platform to capture ultrasensitive, longitudinal biochemical monitoring of immune effectors in sepsis patients and develop dynamic disease models linking biochemical trends to...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $411,475 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to engineer a multiplexed biomaterial-based bioluminescent biosensor platform for real-time sepsis diagnosis and precision immunotherapy guidance. The recipient will develop a rapid ex vivo biosensor using biomaterial-immobilized complementation antibody pairs to dynamically sense proteomic...
- The National Institute of General Medical Sciences awarded the University of Wisconsin System $418,331 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for advanced statistical methods for microbiome data analysis. The award funds development of innovative batch-effect correction methods, meta-analysis techniques, and robust causal-inference tools to address methodological gaps in microbiome research. The recipient will develop and disseminate...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $412,201 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how metabolic microenvironments direct immune cell plasticity and function. The research project develops and applies an organotypic array for culture in live-cell environments (ORACLE), a micropatterned 3D hydrogel platform with functional vasculature that enables spatial and...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $192,330 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of intestinal microbiota in sepsis mortality. The project will elucidate mechanisms by which gut microbial dysbiosis influences sepsis outcomes through a five-year research effort running through May 31, 2031, at Yale's New Haven, Connecticut location. The research combines microbiota...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $413,001 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational systems for analyzing single-cell and spatial transcriptomics experiments. The recipient will create computational methods to improve downstream analysis of gene-expression data from single-cell and spatial transcriptomics experiments, which measure genome-wide expression in...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $124,929 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on how epithelial architecture regulates amoeboid migration strategies in vivo. The research examines cell migration through tissues, with focus on leukocyte movement within epithelial layers. Work uses intravital imaging in zebrafish to characterize how mechanical confinement drives...
- The National Institute of General Medical Sciences awarded Duke University $446,410 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, R01GM163225) to develop and validate statistical methods for identifying disease subtypes in patient populations, with application to sepsis. The project develops three classes of Bayesian statistical approaches designed to address limitations in standard clustering techniques: Bayesian multiview pyramids to handle...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $310,405 on September 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for development of causal inference methods for complex biomedical data. The project develops distributional balancing methods to support causal inference in critical care settings where standard assumptions—no unmeasured confounding, single-time exposures, and ideal measurement—rarely hold. The...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $100,228 on February 13, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop engineered cell-based systems that detect and treat sepsis through synthetic receptors targeting alarmin proteins S100A8 and S100A9. The project will explore two complementary cell engineering strategies: engineering cells to constitutively secrete therapeutics that modulate...
The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $123,309 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for improving sepsis diagnosis through plasma metagenomic sequencing. The research addresses the challenge of timely and accurate sepsis diagnosis in critically ill patients by analyzing microbial and host cell-free DNA (cfDNA) in blood plasma. Current diagnostic approaches suffer from limited sensitivity and long turnaround times. The recipient has developed a laboratory method enriching microbial cfDNA over 200-fold on average to overcome its low natural fraction in plasma. During the K99 phase (mentored research career development), the investigator will develop bioinformatic and statistical methods to differentiate infection-derived microbial cfDNA from in vitro contamination and to distinguish true pathogens from commensal background microbes. The subsequent R00 phase (independent research career development) will identify differences in host cfDNA fragmentation patterns between sepsis and non-infectious critically ill patients and analyze tissue-specific fragmentation patterns to localize infection and organ damage. The award runs through August 31, 2028, and performance occurs in Madison, Wisconsin. This is a project grant, the standard assistance type for investigator-initiated research under NIGMS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.3k | 8/24/26 |