Project Grant K08GM164635
- Federal Project Grant Award Summary The Washington University has been awarded $388,750 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for a Project Grant commencing March 1, 2026, with completion targeted for January 31, 2030. The award funds fundamental biomedical research investigating phosphatidylserine (PS) neighborhood proteins on apoptotic cells and their role in efferocytosis—the process by which...
- Federal Project Grant Award Summary The Washington University received a $483,175 Project Grant award effective June 1, 2026, through January 1, 2031, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds fundamental basic research to elucidate mechanosensitive mechanisms that regulate cellular transcription and cell-to-cell signaling during tissue morphogenesis and patterning. The research...
- Federal Project Grant Award Summary The Washington University received a $410,520 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through January 31, 2031. This award funds fundamental research to uncover the molecular principles of intracellular electrochemistry, with particular focus on how living systems orchestrate buffering environments to support diverse cellular...
- Federal Grant Award Summary Washington State University received a $765,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through May 31, 2030. This award supports fundamental basic research investigating the molecular and neuronal mechanisms that limit stress responses in living organisms. The research employs Caenorhabditis elegans as a model organism to...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $249,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through July 31, 2028. This research initiative investigates cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA), serotonin's primary metabolite, as a reliable biomarker for detecting secondary...
- Federal Project Grant Award Summary The Washington University received a Project Grant award of $427,625 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award supports fundamental research investigating the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research employs advanced...
- Federal Project Grant Award Summary The University of Cincinnati's Sponsored Research Services Division received a $405,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through May 31, 2030. This award supports fundamental research investigating the critical interaction between erythrocytes (red blood cells) and the endothelium following traumatic injury...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a $521,963 Project Grant effective August 1, 2025, through June 30, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative investigates the role of gut serotonergic signaling in traumatic brain injury (TBI) pathogenesis, addressing a significant gap in understanding the...
- Federal Grant Award Summary The University of South Florida received a $568,920 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective April 17, 2026 through March 31, 2031. This research initiative will investigate how traumatic brain injury (TBI)-induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis affects...
- Federal Project Grant Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University a $2.78 million Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective September 1, 2025, through August 31, 2029. This award supports fundamental basic research investigating the role of the ribosome and translation factors in mediating cellular stress signaling. The research focuses on understanding how cells recognize and respond to chemical...
The Washington University, through its Office of Sponsored Research Services, received a $200,613 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026 through May 31, 2029. The research project investigates the role of proton-sensing G protein-coupled receptors (PSGPCRs), specifically GPR4 and GPR68, in the pathophysiology of combined traumatic brain injury (TBI) and hemorrhagic shock (HS). The funded research will deliver scientific knowledge regarding how these pH-sensitive receptors contribute to endothelial barrier dysfunction and cerebral edema in trauma patients, with particular emphasis on understanding how systemic acidosis during hemorrhagic shock exacerbates receptor-mediated endothelial activation. The project encompasses three specific research aims designed to characterize PSGPCR expression patterns following trauma and hemorrhagic shock; elucidate the mechanisms by which PSGPCR activation affects cerebral endothelial cell permeability and intracellular signaling; and evaluate the therapeutic potential of PSGPCR inhibition in mitigating neurobehavioral deficits. Utilizing an established murine model of combined TBI and HS, this fundamental biomedical research addresses a critical gap in understanding the molecular mechanisms underlying life-threatening complications in trauma patients, particularly those with TBI, where mortality rates double when accompanied by hemorrhagic shock.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.6k | 5/14/26 |