Project Grant R01GM165318
- The National Institute of General Medical Sciences awarded California Institute of Technology $446,219 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance selective reactions of carbocations in synthetic chemistry. The funded research expands enantioselective C-H insertion reactions of catalytically generated vinyl carbocations to access diverse cyclic and polycyclic systems. The work develops innovative electrophilic reactions and...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $467,500 to the California Institute of Technology on May 11, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The research investigates the evolution of symbiotic relationships between rove beetles (Staphylinidae) and ant colonies, focusing on how free-living beetle species transition into obligate symbionts dependent on host ant colonies. The work...
- The National Institute of General Medical Sciences awarded California Institute of Technology $164,190 on January 1, 2026, to conduct structural investigation of the central components of the CD4+ T cell immunological synapse through cryo-electron microscopy and engineered virus-like particle methods. Under the Biomedical Research and Research Training program (CFDA 93.859), the recipient will determine experimental structures of peptide-MHC complexes engaged with full-length T cell receptor-CD3...
- The National Institute of General Medical Sciences awarded California Institute of Technology $225,564 on January 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an enantioselective dearomative cyclization strategy for synthesizing quinolizidine natural products. The research focuses on converting pyridine into enantioenriched quinolizidines in a single synthetic step using palladium catalysis and dynamic kinetic resolution. High-throughput data...
- The California Institute of Technology (Caltech) received a $672,155 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on November 15, 2021 to complete the project by October 31, 2024. The grant falls under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and understanding of major problems. Specifically,...
- The National Institute of General Medical Sciences awarded Molecular Instruments, Inc. $306,788 on September 30, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to advance probe technology for ultrasensitive RNA imaging via hybridization chain reaction (HCR). The project develops and refines in situ amplification methods based on HCR mechanism to overcome multi-decade limitations in RNA fluorescence in situ hybridization (RNA-FISH). Specifically, the work...
- Summary The California Institute of Technology received a $1.46M Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded August 1, 2025, with a completion date of July 31, 2029. The grant funds research to miniaturize time-resolved fluorescence (TRF) and fluorescence lifetime imaging (FLIM) measurements using entangled photons and on-chip...
- The National Institutes of Health Office of the Director awarded California Institute of Technology $1.119 million on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop RAMEN (Recursive Assignment Mapping and Enrichment of Nanobodies), a platform for generating comprehensive, validated nanobodies targeting proteins across the human proteome. The project addresses a fundamental bottleneck in biomedical research: the limited availability and specificity of...
- Federal Cooperative Agreement Summary California Institute of Technology (Caltech) received a $3.18 million Cooperative Agreement from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period September 1, 2025 through August 31, 2027. The award funds research to develop next-generation photoacoustic computed tomography (PAT) technology that significantly advances deep-tissue optical imaging capabilities. The...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
The National Institute of General Medical Sciences awarded the California Institute of Technology $1,979,208 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and advance hybridization chain reaction methods for multiplex, quantitative, high-resolution imaging of RNA, protein, and molecular complexes in biological specimens. The research addresses longstanding limitations in in situ hybridization and immunohistochemistry methods by leveraging dynamic nucleic acid nanotechnology to enable simultaneous imaging of multiple molecular targets at high spatial resolution in whole-mount vertebrate embryos and thick tissue sections. The work will build capabilities for spatial exploration of protein-protein interactions and gene regulatory networks in systems relevant to human development and disease. Caltech, headquartered in Pasadena, California, serves as the recipient. Place of performance is Pasadena, CA 91125. The period of performance runs from September 1, 2026, through August 31, 2030. This is a Project Grant, the standard assistance type for investigator-initiated research under NIGMS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 8/13/26 |