Project Grant R01CA325352
- The National Institute of General Medical Sciences awarded the California Institute of Technology $1,979,208 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and advance hybridization chain reaction methods for multiplex, quantitative, high-resolution imaging of RNA, protein, and molecular complexes in biological specimens. The research addresses longstanding limitations in in situ hybridization and immunohistochemistry methods by...
- The National Institute of General Medical Sciences awarded California Institute of Technology $164,190 on January 1, 2026, to conduct structural investigation of the central components of the CD4+ T cell immunological synapse through cryo-electron microscopy and engineered virus-like particle methods. Under the Biomedical Research and Research Training program (CFDA 93.859), the recipient will determine experimental structures of peptide-MHC complexes engaged with full-length T cell receptor-CD3...
- The National Institute of General Medical Sciences awarded California Institute of Technology $225,564 on January 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an enantioselective dearomative cyclization strategy for synthesizing quinolizidine natural products. The research focuses on converting pyridine into enantioenriched quinolizidines in a single synthetic step using palladium catalysis and dynamic kinetic resolution. High-throughput data...
- The National Institute of General Medical Sciences awarded the University of California, Davis $672,980 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing program title) to conduct research engineering cell-cell adhesion through intercellular junction mechanisms. The research addresses the design and development of monoclonal antibodies targeting distinct cadherin conformations—strand-swap dimers and X-dimers—to engineer cell-cell...
- The National Institutes of Health Office of the Director awarded the Trustees of Boston University $1,144,500 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop nanobody-based probes that enable precise, multiplexed, and genetically-encoded perturbations to protein conformations and states in human cells. The work will generate a novel class of probes to realize large-scale, unbiased protein interaction mapping through pooled screening methodologies,...
- The National Institutes of Health Office of the Director awarded the University of California, Berkeley $2,397,234 under the Trans-NIH Research Support program (CFDA 93.310) on July 15, 2026, for the acquisition and installation of a Nanoscribe Quantum X Align system in the Marvell Nanofabrication Laboratory. The instrument enables three-dimensional micro- and nano-printing with sub-micron resolution and sub-100-nanometer feature control across centimeter-scale areas. It supports two-photon...
- The National Institute of General Medical Sciences awarded Partillion Bioscience Corp $979,071 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanovial kits for large-scale cell-cell interaction sequencing. Partillion will expand compatibility of nanovials—engineered hydrogel microcontainers that compartmentalize single-cell and cell-pair interactions—across widely used off-the-shelf single-cell sequencing chemistries to broaden user...
- The National Institute of General Medical Sciences awarded Battelle Memorial Institute's Pacific Northwest National Laboratory $492,167 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-throughput multiomic platform for simultaneous single-cell profiling of proteins, transcripts, and metabolites. The platform integrates novel chemistry, advanced mass spectrometry, and automated nanodroplet processing to analyze thousands of individual...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California Santa Cruz $234,750 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a de novo binder-luciferase platform for multiplexed protein detection in Western blots and lateral flow assays. The project will replace antibody-based detection reagents with computationally designed, thermostable de novo...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
The National Institutes of Health Office of the Director awarded California Institute of Technology $1.119 million on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop RAMEN (Recursive Assignment Mapping and Enrichment of Nanobodies), a platform for generating comprehensive, validated nanobodies targeting proteins across the human proteome. The project addresses a fundamental bottleneck in biomedical research: the limited availability and specificity of high-quality antibodies for protein detection. Current methods cannot simultaneously achieve the scale and specificity required to produce multiple independent reagents per protein while ensuring binding accuracy. RAMEN resolves this scale-specificity paradox through split-and-pool barcoding, linking ultra-high complexity nanobody libraries exceeding 10 billion variants to their protein targets. The platform consists of two components: RESOLVE, which uses split-and-pool assignment to link nanobody libraries with targets at scale while assessing specificity, and a second component detailed in the source narrative. Performance runs through August 31, 2031, with work conducted in Pasadena, California. The funding is assistance classified as a Project Grant with $1.119 million obligated.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/21/26 |