Project Grant R35GM162340
- Federal Grant Award Summary The California Institute of Technology received a $149,264 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective January 20, 2026, with completion targeted for September 24, 2028. The award supports the development of a concise dearomative synthesis approach for quinolizidine natural products—complex nitrogen-containing compounds with significant...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS), under its Biomedical Research and Research Training program (CFDA 93.859), awarded a $150,104 Project Grant to the University of California, Los Angeles beginning March 1, 2026 and extending through August 31, 2028. The research project, titled "Data-Science Guided Study and Design of Phosphoranyl Radical-Mediated Reactions," will deliver a predictive machine learning model explaining phosphoranyl...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Berkeley $151,041 under the Biomedical Research and Research Training program (CFDA 93.859) on January 15, 2026. This Project Grant supports fundamental research in synthetic chemistry and photocatalysis with applications to drug discovery. The research aims to develop supramolecular host structures that function as photocatalysts to enable novel photochemical reactions for...
- Federal Project Grant Award Summary The California Institute of Technology received a $109,076 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective January 1, 2026 through August 31, 2028. The award funds structural investigation of the central components of the CD4+ T cell immunological synapse, specifically advancing understanding of how T cell receptors (TCR) and coreceptors engage...
- Federal Grant Award Summary The University of California, Berkeley received a $149,264 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on February 8, 2026, with completion targeted for November 16, 2028. The award supports fundamental research on site-selective carbon-hydrogen (C-H) borylation directed by noncovalent interactions, which aims to develop systematic and tunable...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Scripps Research Institute $874,000 under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant spanning August 1, 2025, through June 30, 2030. This award supports the development of enantioselective and site-selective C-H (carbon-hydrogen) activation reactions using bifunctional ligands for pharmaceutical synthesis and chemical biology applications. The...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $226,560 under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel catalytic methods for synthesizing saturated, nitrogen-containing heterocycles using mechanism-aware machine learning models. The project, which commenced on March 1, 2026, and concludes on December 30, 2028, addresses a critical bottleneck in active pharmaceutical ingredient (API)...
- Federal Project Grant Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Berkeley $1,479,729 on May 6, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research in synthetic organic chemistry with direct applications to human health. The project, titled "New Bond Disconnections in the Streamlined Synthesis of Complex Bioactive Molecules," will develop novel synthetic strategies and...
- Federal Grant Award Summary The Scripps Research Institute received a $524,400 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2025, with completion targeted for April 30, 2030. The award supports fundamental research in catalytic chemistry aimed at developing novel synthetic methodologies for the functionalization of alkenes and alkynes. The research program focuses on...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant to Harvard College's Office for Sponsored Programs on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds research into enantioselective hydrochlorination of alkenes through cooperative catalysis and dynamic kinetic resolution of quaternary stereocenters. The primary deliverable is the development of a...
The National Institute of General Medical Sciences (NIGMS) awarded California Institute of Technology a $446,219 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective March 1, 2026, with completion expected by December 31, 2030. This MIRA (Maximizing Investigators' Research Award) renewal grant funds fundamental research in carbocation chemistry to develop novel synthetic methodologies leveraging catalytically generated vinyl carbocations for construction of complex, enantioenriched molecular frameworks applicable to bioactive compound development. The award supports three primary research thrusts: expansion of enantioselective C-H insertion reactions to access diverse cyclic and polycyclic systems; development of electrophilic reactions and cross-coupling methodologies involving vinyl carbocations; and creation of advanced biocatalysts including chiral IDPI catalysts and engineered protein enzymes for selective transformations. Additionally, the project advances mechanistic understanding of carbocation chemistry through computational and experimental studies, and applies microcrystal electron diffraction (microED) techniques to structural studies of reactive intermediates. The anticipated outcomes include transformative synthetic methodologies and fundamental insights into carbocation reactivity and catalysis that address longstanding challenges in organic synthesis and support biomedical innovation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.2k | 2/19/26 |