Project Grant R01GM164579
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $458,050.00 to Marquette University to conduct research on the temperature-sensitive structures and processes that underlie fertility in nematode species. The key objectives of this 3-year project are to: 1) Determine how the stability of the synaptonemal complex, a critical meiotic structure, contributes to the...
- The National Institute of Child Health and Human Development awarded the University of Toledo $448,793 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate spermatozoa head-kinking mechanics and their role in male fertility. The research addresses molecular and cellular mechanisms underlying human spermatozoa navigation and egg fertilization. The project will employ rabbits as a genetic model and high-resolution microscopy to...
- The National Institute of Child Health and Human Development awarded the University of Southern California $347,919 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to decipher the role of RG motifs in piRNA-mediated silencing and transgenerational fertility. The research investigates how arginine/glycine (RG) motifs in PIWI-interacting RNA (piRNA) pathway proteins PRG-1 and HRDE-1 regulate germline gene expression...
- The National Institute of General Medical Sciences awarded Louisiana State University Health Sciences Center-Shreveport $516,250 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate genome architecture and gene control in response to stress. The research examines dynamic three-dimensional rearrangements of genome topology during the heat shock response in budding yeast, with focus on how heat shock factor 1 (HSF1) drives concerted structural...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded The Johns Hopkins University a $2.98 million Project Grant (CFDA 93.113, Environmental Health program) effective September 15, 2025 through September 14, 2029 to conduct research on epigenetic mechanisms enhancing transcriptional response to environmental heat stress. The research will employ advanced single-molecule tracking (SMT) technology to directly image endogenous, tagged...
- Federal Project Grant Award Summary The University of Oregon received a $500,000 Project Grant award from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective August 1, 2025, through July 31, 2028. This research initiative, titled "The Intersection of Pollutants and Temperature on the Neurobiology of Reproduction," delivers fundamental scientific research investigating how elevated temperatures and...
- The National Institute of General Medical Sciences awarded the University of Arkansas $401,254 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year project investigating the genetic basis of post-transcriptional regulation of cellular stress defenses. The project applies quantitative and high-throughput genetic approaches using budding yeast (Saccharomyces cerevisiae) to understand how natural genetic variation influences the...
- The National Institute of Child Health and Human Development awarded Oregon Health & Science University $826,077 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate CFTR inhibition as a nonhormonal contraceptive approach. The research project examines how blocking the cystic fibrosis transmembrane conductance regulator (CFTR) in cervical cells increases mucus viscosity, rendering it impenetrable to sperm. The investigator's...
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center, Inc. $129,377 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate relationships between sexual behavior rhythms, core body temperature, and sleep in female mice and their implications for fertility. The research will identify brain circuits regulating female sexual behavior rhythms, determine whether mild cooling...
- The National Science Foundation Division of Biological Infrastructure awarded the University of Oregon $1,051,508 on July 15, 2026, under the Biological Sciences program (CFDA 47.074) to investigate the genetic basis of regulatory evolution in threespine stickleback fish through single-cell genomic and computational approaches. The research determines which cell types respond to environmental shifts and how the same genetic variants produce different outcomes across environments, using...
The National Institute of General Medical Sciences awarded the University of Oregon $337,874 on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate sex-specific regulation by the heat shock response pathway in heat-induced infertility. The research examines how the conserved heat shock response pathway, led by the transcription factor HSF-1, drives sexually dimorphic germ cell responses to heat stress. The project tests the hypothesis that differential HSF-1 regulation between males and females produces sex-specific genomic instability in developing germ cells, with focus on DNA transposon activity and transgenerational epigenetic inheritance. Prior work by the investigator demonstrated that male Caenorhabditis elegans display heat-induced sperm-specific DNA damage and subfertility concurrent with elevated transposon activity, while HSF-1 protects developing eggs from heat-induced damage and displays germ cell-specific localization. The proposed studies will clarify mechanisms by which environmental heat stress compromises fertility, with implications for understanding heritable genomic changes across species. Performance occurs in Eugene, Oregon, with a completion date of April 30, 2031. This is a Project Grant, the standard NIH R01 mechanism for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $337.9k | 8/3/26 |