Project Grant R01ES037774
- This $440,000 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research at Northwestern University to create an unbiased and global map of the cellular response to environmental proteotoxic stress. The project will integrate cutting-edge chemical-genetic screening with computational analysis to identify critical components, functions, and regulatory nodes in the proteostasis network that cells...
- This $147,486 Project Grant awarded by the National Institute of Environmental Health Sciences (CFDA 93.113 - Environmental Health) to Yale University supports research to investigate the effects of environmental stressors, such as changes in temperature and exposure to arsenic, on pre-mRNA processing in the freshwater green alga Chlamydomonas reinhardtii. The project aims to determine how these environmental stressors induce specific changes in alternative splicing and alternative...
- The National Institute of General Medical Sciences (NIGMS) awarded a $525,416 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Johns Hopkins University. This 5-year grant supports fundamental scientific research focused on two key cellular processes: the regulation of gene expression through transcription and the repair of DNA damage using the non-homologous end joining (NHEJ) pathway. The research aims to elucidate the intricate mechanisms behind...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $380,587 to The Johns Hopkins University from January 1, 2025 to December 31, 2029. The project aims to develop new integrated technologies to investigate how distinct molecular programs drive cell behaviors and cellular responses to perturbations at single-cell resolution. The research will focus on understanding...
- This $137,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the epigenetic mechanisms underlying the heat shock response in bacteria. The award aims to investigate how exposure to heat stress leaves an imprint on bacterial cells that improves their ability to respond to future heat challenges, as well as how this memory impacts antibiotic sensitivity....
- This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...
- This Project Grant award of $147,486 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research by Thomas Jefferson University (doing business as Sidney Kimmel Medical College) to investigate the impact of oxidative stress on centromere integrity. The key objectives are to: 1) Investigate the DNA damage response at the centromere and the contribution of DNA repair factors in maintaining centromere...
- This $781,268 Project Grant awarded by the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) will fund research at the University of Southern California to investigate the cardiovascular health impacts of environmental exposures to heat stress and wildfire smoke over the life course. The 5-year study, running from June 2025 to April 2030, will leverage the MetaAIR2 cohort of 400 young adults to examine how these exposures, both independently and jointly,...
- The Johns Hopkins University was awarded a $1.2 million Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences to study the effects of mechanical stress and phenotype switching on human stem cell-derived vascular smooth muscle cells. The grant was awarded on January 1, 2022 with a completion date of December 31, 2025 under the Biological Sciences program (CFDA 47.074). This program aims to promote progress in the biological sciences and strengthen the...
- This is a Project Grant award of $165,108 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health federal grant program (CFDA 93.113). The grant is being awarded to the University of North Carolina at Chapel Hill to study the effects of gestational exposure to extreme heat and neighborhood heat vulnerability on early childhood blood pressure trajectories. The research aims to investigate the associations between exposure to extreme heat during...
The Johns Hopkins University was awarded a $2,979,007 Project Grant from the National Institutes of Health's National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) to conduct research on "Epigenetic Mechanisms Enhancing Transcriptional Response to Environmental Heat Stress." The 4-year project, running from September 2025 to September 2029, will apply advanced live-cell imaging techniques and biochemical assays to investigate how transcription factors and chromatin remodelers collaborate to establish an "open chromatin" state that enhances heat shock factor 1 (HSF1) binding and activation, enabling a rapid and efficient cellular response to environmental heat stress. The research aims to provide mechanistic insights into this epigenetic regulatory process, which could have broad implications for understanding environmental stress response pathways across diverse organisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 9/13/25 |