Project Grant R01GM164480
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $435,412 to the University of Houston System under the Biomedical Research and Research Training program (CFDA 93.859) for a two-year project commencing September 1, 2025. Principal Investigator Dr. Yu Liu will develop TO-Triplex-Seq, a novel whole-genome sequencing technology designed to identify and map RNA-DNA triple helix structures genome-wide. The technology leverages the differential affinity of...
- Federal Project Grant Award Summary The University of Houston System received a $431,750 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through March 31, 2031. This award supports fundamental biomedical research investigating the role of copper transporter 1 (CTR1) oligomeric state transitions in copper homeostasis and neuronal differentiation. The research employs...
- This $140,314 National Science Foundation project grant under the Integrative Activities program (CFDA 47.083) will fund research and training related to exosome proteomics analysis and biomarker discovery for cancer diagnostics. Louisiana Tech University will collaborate with the University of Houston to identify glioblastoma-specific protein biomarkers in exosomes purified from biofluids using disease-specific surface markers. The Principal Investigator and one graduate student will receive...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $1.32 million Project Grant to the University of Texas Medical Branch at Galveston under the Biomedical Research and Research Training program (CFDA 93.859). The award, effective September 1, 2025, and extending through May 31, 2030, supports a comprehensive research program focused on deciphering mechanosignaling mechanisms through development of an advanced methodology framework. The principal...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $429,000 Project Grant award dated March 6, 2026, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a five-year research initiative (completion date February 28, 2031) investigating the regulation of endoplasmic reticulum-selective autophagy (ER-phagy) during cellular stress conditions. The research...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $390,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through June 30, 2030. This award funds fundamental biomedical research investigating tissue-specific regulation of autophagy by proppins (B-propellers that bind phosphoinositides), with the objective...
- Federal Project Grant Award Summary Michigan Technological University received a $383,801 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced biosensing technology for clinical diagnostics. The award, effective May 1, 2026 through February 28, 2031, funds the development of a cost-effective, scalable, and multiplexed biosensing platform based on molecularly imprinted polymers...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $670,800 Project Grant award effective September 1, 2025, through May 31, 2029, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This investigator-initiated basic research award supports fundamental scientific investigation into the synthesis, trafficking, and regulation of phosphatidylserine (PS), the most...
- Federal Project Grant Award Summary The National Science Foundation's Division of Chemistry has awarded the University of Houston System at its University of Houston-Clear Lake campus $249,995 under the Mathematical and Physical Sciences (CFDA 47.049) program to develop multimodal-enhanced Raman scattering (MERS) technology for ultrasensitive molecular detection of environmental pollutants. Under the leadership of Professor Tej B. Limbu, the research team will design and optimize MERS substrates...
The University of Houston System received a $431,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026, with a completion date of February 28, 2030. The award supports the development of an Integrated Nanophotonic Imaging and Spectroscopy Technology (INSPECT) platform designed to enable scalable, multi-parametric single exosome analysis without requiring extensive sample purification. The technology leverages three nanoplasmonic enhancing mechanisms—localized surface plasmon resonance (LSPR) imaging, plasmon-enhanced fluorescence (PEF), and surface-enhanced Raman scattering (SERS)—integrated onto a single nanophotonic chip to simultaneously acquire structural and compositional information from individual exosomes. This research addresses critical limitations in current exosome analysis methodologies, which typically demand extensive sample preparation, inadequate sensitivity and specificity, and reliance on DNA amplification techniques. By developing this purification-free analysis approach, the project aims to advance exosome-based research and diagnostic applications across multiple fields, including cancer biology, neurological disorders, regenerative medicine, liquid biopsy, and drug delivery. The technology is intended to reduce technical barriers and sample volume requirements while improving detection accuracy and resolution for single exosome profiling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 5/5/26 |