Project Grant R01GM162824
- The National Institute of Allergy and Infectious Diseases awarded Albert Einstein College of Medicine $780,787 on January 27, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on how T cell receptor recognition of peptide ligands shapes memory CD8+ T cell programming. The research will identify features of T cell epitopes, T cell receptor structural modes of recognition, T cell receptor signaling pathways, and genetic and epigenetic regulators...
- The National Institute of General Medical Sciences awarded New York University $185,462 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning schemes that predict rare biomolecular events using short molecular dynamics trajectories rather than computationally prohibitive long simulations. The research addresses the challenge of characterizing infrequent biological phenomena—such as insulin dimer dissociation, which can require...
- The National Science Foundation Division of Information and Intelligent Systems awarded Icahn School of Medicine at Mount Sinai $204,412 on July 1, 2026, under the Computer and Information Science and Engineering program (CFDA 47.070) to develop structure-aware protein language models for decoding immune recognition. The research will generate three-dimensional models of paired T cell receptors, represent local structural environments as symbolic tokens, and integrate sequence, structure, and...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Albert Einstein College of Medicine $199,667 on May 15, 2026, under the Research Infrastructure Programs (CFDA 93.351) to establish a comprehensive protein stability platform for multi-user research. The platform combines full-spectral fluorescence monitoring with dynamic light scattering (DLS) and static light scattering (SLS) plate reading, sealable optical plates for thermal cycling, and...
- The National Institute of General Medical Sciences (NIGMS) awarded Albert Einstein College of Medicine $370,979 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of dynein and KIF1A motor proteins in cellular transport. The research employs advanced techniques including MINFLUX microscopy, single-molecule Förster resonance energy transfer, optical tweezers, and unnatural amino acid labeling to elucidate how...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $462,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 7, 2025, with completion targeted for June 30, 2027. The research initiative focuses on designing improved T cell epitopes (antigenic peptides) to enhance the efficacy of T cell-based vaccines and adoptive cell therapies. The project will...
- The National Institute of General Medical Sciences awarded Albert Einstein College of Medicine $420,000 on September 1, 2026, to investigate the molecular mechanisms controlling a diapause-like dormant cell state under CFDA 93.859 (Biomedical Research and Research Training), assistance type Project Grant R35GM163637. The research characterizes how somatic cells adopt a reversible, quiescence state resembling embryonic diapause in response to cellular stress and damage. Work addresses three...
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $420,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and deploy genetic interaction mapping tools in bacteria. The project will construct a comprehensive genetic interaction network in Escherichia coli by developing a barcoded CRISPR strategy to systematically profile all pairwise genetic interactions (approximately 10 million) and...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded $763,328 to the Research Foundation of the City University of New York (doing business as the Advanced Science Research Center) on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to develop artificial intelligence-driven methodologies for designing dynamic protein structures. The project will test whether existing designed proteins exhibit different conformational dynamics than natural...
- The National Institute of General Medical Sciences, a component of the National Institutes of Health within the Department of Health and Human Services, awarded $1.764 million to Albert Einstein College of Medicine on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular mechanisms governing the elongation-to-termination transition of RNA polymerase II-dependent transcription. The funded research investigates how RNA...
The National Institute of General Medical Sciences awarded Albert Einstein College of Medicine $361,200 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for predicting and simulating interactions between cell surface proteins with multiple domains in the immunoglobulin fold. The project addresses a fundamental challenge in structural biology: current experimental methods cannot reliably measure transient interactions among cell surface proteins on a systematic level, and even state-of-the-art deep-learning approaches such as AlphaFold 3 lack sufficient sensitivity to model these interactions. The research will construct a non-redundant structural database of domain interactions and use it to develop new computational modeling methods capable of predicting which specific domains within multi-domain cell surface proteins are responsible for binding, how domain binding selectivity is determined, and why multiple extracellular domains have evolved. Understanding these mechanisms is critical to decoding the biological function of cell surface receptors and ligands, which are central to cellular adaptation and communication. Work is performed in Bronx, New York, with a period of performance extending from August 15, 2026, through July 31, 2030. The award is classified as a Project Grant, the standard NIH mechanism for investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $361.2k | 7/31/26 |