The University of Connecticut received a $266,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a delivery technology for large messenger RNA (mRNA) applications in cartilage and joint tissues. The university will introduce an innovative platform using DNA-inspired Janus base nanomaterials to help large mRNA enter tissues for biomedical uses from therapeutics to research reagents. Postdoctoral...
The National Institute of General Medical Sciences (NIGMS) awarded a $300,518 Project Grant under CFDA Program 93.859 (Biomedical Research and Research Training) to E&E Bioclub LLC in Indianapolis, IN. The project aims to develop an all-in-one platform for intracellular overproduction of long, single-strand mRNA. This is intended to address challenges with current mRNA manufacturing methods, such as the cost and scalability constraints of in vitro transcription and the difficulty in...
This Project Grant award, valued at $936,000.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The goal of this project is to develop a platform called mRNADesigner, an integrated deep learning model to optimize the 5'UTR, codon usage, and 3'UTR of mRNA sequences simultaneously. This will enable users to design optimal mRNA sequences to enhance protein expression levels and...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Cisterna Biologics, Inc. to develop a novel production and purification process for ultra-pure mRNA. The key objectives are to generate contaminant-free mRNA essential for high-dosage and frequent therapeutic applications, such as enzyme replacement and cancer immunotherapy. The approach involves developing...
This $457,390 Project Grant award from the National Science Foundation's (NSF) Division of Materials Research aims to develop a new mRNA delivery system based on functional phosphoserine (PS) lipids. The award will support research to understand the targeted and immunomodulatory properties of these zwitterionic functional materials for mRNA delivery, with potential applications in gene therapy, protein-replacement therapy, and cancer immunotherapy. Key objectives include enhancing mRNA...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $364,167 to Villanova University to develop novel non-viral gene delivery methods for cell therapies. The key objectives are: The Bracaglia Lab will develop new polymeric gene delivery vehicles to improve the delivery of siRNAs and other payloads to T cells and hematopoietic stem cells (HSCs). Drs. Elmer and Huang will...
This Project Grant award, with ID R01GM157259, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, totaling $337,088, supports the development of a versatile platform for RNA delivery specifically tailored for the central nervous system (CNS). The key objectives are to establish a delivery system capable of high-efficiency RNA transfer, precise cell-specific targeting, and minimal...
This federal Project Grant award of $324,998 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program supports Rejuvenation Technologies Inc. (RTI) in developing advanced therapeutic technologies for in vivo delivery of mRNA to stem and progenitor cells. The key objectives of this award are to: 1) generate a library of rationally designed peptides for targeting three progenitor cell types, 2) utilize computational...
This federal Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop design rules and quantify the relationships between polymer and nucleic acid structure, and the assembly, physical properties, delivery, and dynamic behavior of polyelectrolyte complex micelles (PCMs). The project will use techniques like small-angle X-ray scattering, electron microscopy, and fluorescence imaging to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $833,652 to the University of Connecticut to develop novel DNA-inspired biomaterials for effective intracellular delivery of messenger RNA (mRNA) therapeutics and research tools. The research aims to optimize the biointerface properties of Janus base nanoparticles (JBNPs) using computational molecular design and experimental validation, with the goal of enhancing mRNA delivery at both the cellular and systemic levels. Key focus areas include improving endosomal escape and reducing protein corona formation to overcome current limitations of existing mRNA delivery vehicles. The University of Wisconsin-Madison received a $193,357 sub-award to further study the biointerface properties and intracellular delivery capabilities of the JBNPs. If successful, this research could enable more effective delivery of mRNA-based therapeutics and gene editing tools for a variety of biomedical applications.