The Project Grant award R01GM155969, funded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports the development of a novel biomaterial platform for effective intracellular delivery of messenger RNA (mRNA) therapeutics and research tools. The $424,451 award to the University of Connecticut aims to optimize the biointerface properties of DNA-inspired Janus base biomaterials using computational modeling to...
The National Science Foundation awarded a $750,000 Project Grant to Rutgers, The State University under the Engineering program (CFDA 47.041) from September 1, 2022 to August 31, 2025. The grant funds research to develop an injectable nanoparticle therapy to restore strength and length to damaged tendons and ligaments. Specifically, the university will investigate combining a thermosensitive polymer and crosslinking agent to stabilize joints by quickly strengthening and returning tissues like...
Through a $1,000,000 Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, Optimeos Life Sciences, Inc., a for-profit biotechnology company, is developing a non-viral platform for delivering mRNA-based gene therapies. The project aims to validate a polymer-lipid hybrid formulation that can safely and repeatedly deliver genetic instructions to patients with rare urea cycle disorders, overcoming limitations of current...
This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
This $457,390 Project Grant award from the National Science Foundation's (NSF) Division of Materials Research aims to develop a new mRNA delivery system based on functional phosphoserine (PS) lipids. The award will support research to understand the targeted and immunomodulatory properties of these zwitterionic functional materials for mRNA delivery, with potential applications in gene therapy, protein-replacement therapy, and cancer immunotherapy. Key objectives include enhancing mRNA...
This National Science Foundation (NSF) Project Grant award under CFDA 47.041 Engineering program provides $285,630 to the University of New England to conduct research on the molecular mechanisms of articular chondrocyte mechanotransduction and its relation to osteoarthritis development. The 3-year project, which commenced on October 1, 2024, aims to elucidate how mechanical forces are transmitted across chondrocyte cell surfaces and how this affects cartilage health. The research will examine...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is providing $199,006 over a 3-year period (9/1/2024 - 8/31/2027) to the University of Texas at Arlington (UTA) to develop a high-throughput single-molecule nanosensor for characterizing the loading efficiency of gene delivery liposomes. The goal is to create a novel optical-electrical sensor that can quickly and accurately quantify the encapsulation efficiency of circular DNA (cDNA)-loaded...
The National Science Foundation (NSF) awarded a $274,980 SBIR Phase I Project Grant to Cisterna Biologics, Inc. to develop a novel platform for cost-efficient mRNA production in yeast. The project aims to transform yeast cells into efficient mRNA factories and utilize advanced chromatographic techniques for purification, with the goal of reducing mRNA manufacturing costs by 90% compared to current in vitro transcription methods. Key technical objectives include demonstrating stable mRNA fusion...
This $851,000 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop a novel peptoid-based barcode system for high-throughput screening of targeted nucleic acid delivery using gene-encapsulated nanoparticles. The research, conducted by the University of North Texas Health Science Center, will synthesize deuterated...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) award of $274,947 to Lattice Therapeutics Inc. supports the development of a customizable, next-generation RNA delivery particle. The project aims to validate the ability of an engineerable protein nanoparticle platform to efficiently and specifically deliver RNA cargoes to target cancer cells. Key objectives include in vitro evaluation of RNA...