Expanding the design space of polyelectrolyte complex micelles
Active Project Grant Awarded Last action
- Award ID
- R35GM154984
- Recipient
-
University Of Texas At Austin UEI V6AFQPN18437 Part of University Of Texas System
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,146,730
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 43% complete
- Place of performance
- Austin, TX 78712, USA
Award details come from USAspending.gov.
Description
- Abstract
- Polyelectrolyte complex micelles (pcms) are a unique class of self-assembled nanoparticles that form with a core of associated polycations and polyanions surrounded by a neutral corona. The hydrated nature and structural and chemical versatility make pcms an attractive system for delivering hydrophilic payloads while controlling carrier size and stability. While recent studies have shown pcms are effective at delivering nucleic acids, the design process has largely been trial-and-error to this point with few systematic studies focused on defining and predicting PCM properties and behavior in physiological conditions. By leveraging polymer design, controlled self- assembly, and materials characterization techniques, the goal of this proposal, and of our research group, is to develop design rules quantifying the relationships between polymer and nucleic acid structure and PCM assembly, physical properties, delivery, and dynamic behavior. We will use small-angle x-RAY scattering, electron microscopy, and fluorescence imaging to accomplish three broad goals: 1) develop structure-property relationships based on polymer and nucleic acid structure, chemistry, size, and charge density, 2) quantify the effect of PCM component structure on cellular uptake and cargo release, and 3) uncover the mechanism, kinetics, and factors that control nucleic acid exchange between pcms. As each area progresses we will use computational methods to analyze our vast PCM characterization database and establish the scaling laws and relationships driving PCM assembly and function. The proposed work will build the foundation for a new class of pcms with predictive properties tailored to each treatment, aligning our lab goals with the overarching mission of nigms.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $382,863 | |
| Amendment | $382,251 | |
| Original award | $381,616 |
Quick answers
Who received award R35GM154984?
R35GM154984 was awarded to University Of Texas At Austin by National Institute of General Medical Sciences (National Institutes of Health) on September 1, 2024.
How much is award R35GM154984 worth?
$1,146,730 has been obligated on R35GM154984.
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