Project Grant R01GM154933

Award Date 9/25/24
Completion Date 7/31/28
Dollars Obligated $489K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30332, USA
Similar Awards
This federal Project Grant award of $324,998 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program supports Rejuvenation Technologies Inc. (RTI) in developing advanced therapeutic technologies for in vivo delivery of mRNA to stem and progenitor cells. The key objectives of this award are to: 1) generate a library of rationally designed peptides for targeting three progenitor cell types, 2) utilize computational...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin System to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale receptor forces within viscoelastic biomaterials. The key products and services to be delivered include: Quantifying the magnitude and distribution of forces that cells, such...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to improve the efficiency of CRISPR gene editing in human pluripotent stem cells. The goal is to develop a novel carbon nanotube array technology that can efficiently transfer nucleic acids and proteins into these cells to enhance CRISPR-based gene editing and homology-directed recombination. The $275,045 award to Advanced Gene...
This Project Grant award, with a total funding amount of $475,670.00, was provided by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041). The primary objective of this 5-year project, which commenced on December 15, 2024, is to develop a new method for spatiotemporal monitoring of live tissue gene expression. The proposed approach involves a nanowire-based molecular transfer technology that can extract molecules from live cells and transfer them to a hydrogel,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will provide $1,158,570 to Rensselaer Polytechnic Institute (RPI) to explore new approaches for enhancing the function of biomedical and biological interfaces. The research program aims to develop self-assembled, multifunctional coatings that can transform the properties of a wide range of substrates. Specifically, the project will...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $317,623 to Georgia Tech Research Corp to develop novel bioorthogonal chemical reactions and tools. The key objectives are to: 1) create reactive chemical species for target identification of bioactive small molecules; 2) develop proximity labeling tools for interactome studies; and 3) develop biologically compatible directing...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, is focused on establishing a versatile platform for RNA delivery specifically tailored for the central nervous system (CNS). The $337,088 project aims to develop a transformative RNA delivery system that can achieve high-efficiency delivery, precise cell-specific targeting, and minimal cellular disruption. Key aspects...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is for the development of a novel technology called "Precise Area Introduction and Transfection" (PAINT) to enable highly localized and efficient delivery of biomolecules to cells. The $488,753 award, effective September 25, 2024, will fund research to optimize the PAINT system's capability to transiently disrupt cell membranes and introduce cargo such as nucleic acids, proteins, and nanoparticles. The project will also validate the utility of PAINT for modifying human pluripotent stem cell-derived neural organoids. This research is being conducted through a collaboration between Georgia Tech Research Corporation and the University of Wisconsin-Madison. The proposed PAINT technology aims to address limitations of current biomolecule delivery methods by providing precise spatial control and significantly improved delivery efficiency compared to existing microinjection techniques.

Generated 7/1/25, 3:07 AM