Project Grant R01GM149795
Award Date
8/1/24
Completion Date
6/30/28
Dollars Obligated
$868K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
University, MS 38677, USA
Similar Awards
This federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support the development of a "plug-and-play platform for the continuous directed evolution of nonribosomal peptide synthetases (NRPS)." The $240,000 award, spanning from Sep 1, 2024 to Aug 31, 2026, will enable the Baylor College of Medicine to create a live-cell reporter system for NRPS substrate specificity and...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program provides $450,313 to The Johns Hopkins University from June 1, 2025 to May 31, 2030. The purpose of this grant is to investigate the molecular mechanisms and dynamic domain interactions that govern the function of nonribosomal peptide synthetases (NRPSs), which are complex, multi-domain enzymes that synthesize natural products with...
This Project Grant award, provided by the National Science Foundation's Biological Sciences (CFDA 47.074) program, will fund research to characterize the function of an unknown protein, BRESU_2828, and its role in pilus biogenesis across multiple bacterial species. The $563,387 award to the University of Mississippi will investigate how BRESU_2828 influences the synthesis of bacterial pili, which facilitate colonization and biofilm formation. Key activities include global proteomics analysis, in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, is supporting research to uncover the hidden biosynthetic capabilities of fungi. The $495,117 award, spanning January 1, 2025 to December 31, 2029, will enable the University of Wisconsin - Madison to pursue three key areas of investigation: (1) elucidating the products of fungal gene clusters encoding unusual enzymes...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $986,486 Project Grant to the University of California, Berkeley. The goal of this 5-year project, starting on May 6, 2025, is to develop new synthetic disconnections, strategies, and concepts to rapidly produce biologically important and complex molecules. This includes natural products from the Euphorbiaceae and Thymelaeaceae plant families, which...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program Project Grant award to the University of Rochester provides $376,301 to develop an innovative platform that leverages horizontal gene transfer to self-regulate and stabilize microbial consortia. The project aims to create programmable microbial populations capable of maintaining stability across diverse conditions, with potential applications in bioproduction, environmental cleanup, and healthcare. Key objectives...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports two key research efforts: Development of new synthetic methodology to access rare, nitrogen-rich heterocyclic compounds with potential medicinal relevance. This includes expanding the synthesis and application of the diazacyclobutene (DCB) heterocycle, which preliminary data suggests may exhibit anti-parasitic...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing synthetic biology tools and strategies to streamline the sensing and responding capabilities of engineered theragnostic bacteria. The $402,500 award, effective January 1, 2025 through November 30, 2029, will support research conducted by the Cleveland Clinic Lerner College of Medicine of Case...