This Project Grant award, with a total funding of $450,313, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to elucidate the molecular mechanisms that underlie the dynamic behavior of multidomain enzymatic factories known as nonribosomal peptide synthetases (NRPSs). The awardee, The Johns Hopkins University, will leverage nuclear magnetic resonance (NMR)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,600,616 to the University of Wisconsin System for research aimed at engineering promiscuous enzymes to synthesize non-canonical amino acids (NCAAs) as new biological building blocks. The research encompasses mechanistic analysis of pyridoxal-phosphate dependent enzymes that catalyze C-C bond formation, as well as developing...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports two main research initiatives at Baylor University: Project 1 aims to expand the use of NMR-guided directed evolution techniques to create improved metalloenzyme catalysts for practical applications, such as pesticide/chemical weapons remediation, DNA hydrolysis, and phenol oxidation. The research will also help advance...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $585,000 in funding to the University of Texas at Dallas (UTD) for the period of August 1, 2025 to May 31, 2030. The grant supports two key objectives: Developing innovative strategies and platforms for discovering 'natural product'-like macrocyclic peptides as potent and selective modulators of biomolecular interactions. This...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
The National Institute of General Medical Sciences (NIGMS) awarded a $384,896 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Missouri System. The award will fund research to engineer peptide-based biomodulatory materials that can serve as translational platform technologies for various biomedical applications. Specific objectives include using computational and experimental techniques to develop design rules for micellar...
This $306,872 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a commercial prototype for Fluid Discovery, Inc.'s "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." This transformative screening platform combines scalable hardware, label-free mass spectrometry, and advanced computational techniques to...
This $700,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support research at Baylor University to understand the structure and dynamics of enzyme catalysis. The goal is to combine structural biology and kinetics experiments to observe enzyme function in real-time and under different conditions, which can inform the design of new enzymes and inhibitor drugs. Specifically, the research...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research by Vanderbilt University to discover and engineer new classes of ribosomally synthesized and post-translationally modified peptides (RiPPs). The $558,651 award, effective from August 1, 2025 to July 31, 2030, will fund the development of advanced bioinformatics tools to mine metagenomic datasets for novel RiPP...