Project Grant R01GM149693
Award Date
9/1/24
Completion Date
6/30/28
Dollars Obligated
$318K
Funding Federal Agency
Assistant Secretary for Financial Resources
Awarding Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30332, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $524,400.00 to the Scripps Research Institute to develop novel chemical transformations and catalysts to enable more efficient organic synthesis. The funded research aims to address limitations in the current synthetic toolkit by expanding the capabilities for rapid and selective functionalization of carbon-carbon...
This $800,308 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to engineer and evolve enzymes that can catalyze new-to-nature C-C bond forming reactions. The goal is to produce non-canonical amino acids that can expand the diversity of medicinal chemistry. The research encompasses mechanistic analysis of pyridoxal-phosphate dependent enzymes to understand how they generate...
This Project Grant award of $775,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to expand the chemical and functional space through boron-nitrogen heterocycles. The key products and services to be delivered under this 5-year award, which begins on September 10, 2024, include: Developing novel reactivity and selectivity in synthetic organic chemistry using boron-containing compounds that are not possible...
This $444,262 project grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of innovative reagents and methods for the synthesis of oligophosphate constructs. The key products and services to be delivered include: New reagents and methods for synthesizing oligophosphate chains up to pentaphosphorylation and beyond, including those with non-hydrolyzable P-C bonds. These...
The federal Project Grant award R35GM156318, with $471,019 in funding from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859), will be used to develop innovative methods for comprehensive analysis of extracellular glycoproteins and their interactions. The project aims to characterize glycoproteins on cell surfaces and in the secretome, as well as investigate the regulation of glycans on interactions among these extracellular...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,107,534 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to North Carolina State University. The grant funding, which runs from July 15, 2024 to May 31, 2029, will support research to develop novel bioconjugation methods that can selectively functionalize hydrophobic, unactivated, and less abundant amino acids using non-aqueous media. The goal is to provide a chemical tool to target amino acid residues...
This $1,070,764 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate instances of "convergent evolution" in natural product biosynthesis. The goal is to identify molecules of significant biological importance that have survived the natural selection process on multiple occasions, with the potential to inform new approaches to drug discovery. The research...
The National Institute of General Medical Sciences (NIGMS) awarded a $460,413 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Texas at Dallas (UTD) for the development of a novel visible light-induced transition metal-radical hybrid catalytic methodology. The goal is to enable regiocontrolled, mild, and exogenous oxidant-free functionalization of saturated organic compounds, which has broad applications in chemical synthesis and pharmaceutical...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,569 to Vanderbilt University to develop new chemical reactions and reagents for the stereoselective synthesis of valuable organic compounds, including secondary amines, tertiary amines, and vicinal diamines. The goal is to create efficient, metal-free methods to produce these functionally dense, single...