This $360,100 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on novel synthetic methods using supramolecular catalysis to enable pharmaceutical-relevant transformations. The principal investigator at the University of California, Berkeley will develop methods for N-heterocycle reduction, olefin epoxidation, and enantioselective C(sp3)-H oxidation of alkanes....
The National Institute of General Medical Sciences (NIGMS) awarded a $984,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to support research focused on "Expanding Access to Molecular Complexity through Natural Product Synthesis." The project aims to develop new tools and strategies for the synthesis of complex natural products, which can serve as vital medicines and advance the field of organic...
The National Science Foundation Division of Chemistry awarded a $1,050,000 Project Grant to the Scripps Research Institute under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research exploring attached-ring cross-coupling chemistry and its applications. Over a three-year period from August 1, 2022 to July 31, 2025, Professor Ryan Shenvi of Scripps Research Institute will develop new non-precious metal reagents and methods for concise syntheses of...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,542,569 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York. The grant, effective July 1, 2024 through April 30, 2029, will support the development of new copper-catalyzed reactions for the efficient and stereoselective synthesis of chiral amine derivatives and ethers, predominantly saturated heterocycles. The research aims to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $1,116,495.00 in funding to the Regents of the University of California at Riverside to develop sustainable methodologies using earth-abundant nickel-based catalysts for the synthesis of nitrogen-containing molecules. The key objectives are to enable more scalable and cost-effective approaches for producing amines, amides, and...
The National Institute of General Medical Sciences (NIGMS) awarded a $460,413 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Texas at Dallas (UTD) on April 22, 2025. The funding supports the development of a novel visible light-induced transition metal-radical hybrid catalytic methodology for regiocontrolled, mild, and exogenous oxidant-free functionalization of saturated organic groups. The proposed research aims to create a synthetic platform for...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) Project Grant award of $493,243 supports the discovery of new synthetic strategies and concepts to rapidly prepare biologically important and structurally complex natural product molecules from the Euphorbiaceae and Thymelaeaceae plant families. The goal is to develop efficient and convergent methods to access diverse polycyclic frameworks that are increasingly valuable for...
The National Institute of General Medical Sciences (NIGMS) awarded a $122,904 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Los Angeles (UCLA) for the period of July 1, 2024 to June 30, 2026. The goal of this grant is to integrate machine learning (ML) with synthetic chemistry to provide solutions for challenges in medicinal chemistry library preparation, process optimization, and rapid assembly of chiral bioactive...
The National Science Foundation Division of Chemistry awarded a $662,000 Project Grant to the Scripps Research Institute from September 1, 2021 through August 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will support research activities focused on catalytic activation of alkenyl C-H bonds. As part of the Mathematical and Physical Sciences program's goal of strengthening the nation's scientific enterprise through advancing knowledge and understanding of...
The National Institute of General Medical Sciences (NIGMS) awarded a $425,960 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Texas at Austin. The grant supports research to develop catalytic methods for C=X/C=C (X = O, NR) and C-X/C-Y (X = Y = halide) reductive C-C couplings mediated by H2, 2-PrOH, and NaO2CH. This includes catalytic hydrogen auto-transfer reactions that enable direct conversion of lower alcohols/amines to higher alcohols/amines...