This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $425,803 to The University of Mississippi to elucidate the structural attributes and functions of the cytosolic heat shock protein 70 (HSP70) and its role in maintaining cellular integrity and stress response. The research aims to investigate HSP70's lectin-like capacity to bind O-GlcNAcylated proteins, its ability to bind...
This $153,488 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms by which the HSP70 molecular chaperone system interacts with the AAA+ disaggregase HSP104 to target and solubilize toxic amyloid aggregates. The research aims to use biochemical and cryo-EM structural approaches to define the precise interaction between HSP70 and HSP104, and how this...
This Federal Project Grant award of $193,336 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the role of the mitochondrial chaperonin HSPE1 in regulating the GTPase OPA1, which is responsible for mitochondrial inner membrane fusion. The key objectives are to: 1) identify interactors of HSPE1 and HSPD1 using proximity labeling and mass spectrometry, and determine if depletion of these...
This Project Grant award of $272,914 from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) supports research to understand how cells interpret and respond to stress signals. The primary research objectives are to examine: 1) post-transcriptional regulation of genes through mRNA stability, and 2) combinatorial regulation of genes by multiple transcription factors. The research will use experimental techniques like metabolic...
This Project Grant award of $1,188,381 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, supports research to identify novel molecular mechanisms that modulate environmental stress response pathways in diverse animal species. The principal investigator aims to harness evolutionary adaptations in animals like birds, whales, and fish that have evolved to withstand chronic hypoxia and oxidative stress. By...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, supports research to discover the mechanism by which the endoplasmic reticulum (ER) chaperone GRP94 assists in the folding and secretion of insulin-like growth factor (IGF) proteins. The $433,342 award to Brandeis University aims to determine how the GRP94 chaperone interacts with the BIP chaperone to assess client proteins and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, is providing $372,880 to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. to conduct research on the regulation of protein synthesis during cellular stress. The key objectives of this 5-year project are to: 1) understand how the formation of the essential translation initiation factor eIF2...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) aims to investigate the molecular mechanisms and develop treatments for HSPB8-associated dominant rimmed vacuolar myopathy. The $737,528 award, with a project period from Sep 2024 to Aug 2026, will fund the following key efforts: In vitro studies using patient-derived induced pluripotent stem cell (iPSC) myoblasts and a...
This federal Project Grant award for $381,251, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to understand how endoplasmic reticulum (ER) quality control processes, including ER-associated degradation (ERAD) and ER-autophagy (ER-phagy), regulate protein homeostasis in different cell types. The key objectives are to: 1) establish the principles governing the selection of...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to the University of Delaware totals $605,253 and aims to dissect the protective role of cardiac HSP90β ablation/inhibition. The research will examine if removal of cardiac HSP90β confers cardioprotection, particularly by preserving mitochondrial membrane integrity, following ischemic injury. The project will map the binding domains between HSP90β and HAX-1 to test the...