Project Grant R35GM157973

Award Date 5/15/25
Completion Date 2/28/30
Dollars Obligated $433K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Waltham, MA 02453, USA
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This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the mechanism by which the endoplasmic reticulum chaperone GRP94 assists in the folding and secretion of insulin-like growth factor proteins.

The $433,342 award, with a project period from May 15, 2025 to February 28, 2030, will enable the research team at Brandeis University to study how the GRP94 chaperone system interacts with the BIP chaperone to assess, transfer, and properly fold insulin-like growth factor client proteins. Key goals include determining the conditions under which clients are transferred from BIP to GRP94, and how the combined BIP/GRP94 system can perform mechanical unfolding work on bound client proteins. The research will also examine how small molecule inhibitors of the related HSP90 chaperone disrupt the function of the BIP/GRP94 system. This fundamental research aims to advance the understanding of chaperone-mediated protein folding mechanisms and support the development of potential therapeutic interventions.

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