This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $959,190.00 to the University of North Carolina at Charlotte to investigate the role of Hsp70 phosphorylation in proteostasis and the heat shock response. The research aims to study how phosphorylation of the Hsp70 molecular chaperone impacts its function in yeast, particularly regarding the formation of reversible...
This $1,150,541 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to study how chaperone proteins mediate proteasomal degradation. The principal investigator at the University of Missouri System will use in vitro techniques and cryo-electron microscopy to investigate the mechanisms by which the HSP70/CHIP/BAG-1 chaperone complex affects each step of proteasomal...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $153,488 to The Regents of the University of California, San Francisco (UCSF) to advance the understanding of how the AAA+ disaggregase protein Hsp104 interacts with the Hsp70 molecular chaperone system to target and solubilize toxic protein aggregates associated with neurodegenerative diseases. The research aims to define the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $534,160 to support research on the molecular mechanisms underlying protein function. The key focus areas include: Elucidating the mechanisms by which ion transport proteins, such as TMEM175, CLC, IP3Rs, and CLN7, recognize and transport ions across cellular membranes, as well as how their activities are regulated. Investigating...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,189,314 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Washington University to elucidate the roles of protein disaggregases and develop enhanced disaggregases to counter diverse protein-misfolding disorders. This 5-year grant, effective September 1, 2024, aims to better understand how cells maintain protein homeostasis, how proteostasis fails, and how protein disaggregases can be applied to...
This $597,573 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to provide atomic-level insights into the structure, dynamics, interactions, and function of large protein and protein-DNA systems that are significant in biology and human health. The research focuses on two key areas: (1) nucleosomes and large nucleosome arrays mimicking chromatin, and their complexes with...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $459,006 to Marquette University to study the role of molecular chaperone systems in managing protein aggregation associated with neurodegenerative and systemic diseases. The 3-year project aims to define how the HSP110 and HSP104 chaperone systems work together to disassemble different types of protein aggregates, including...
This $433,342 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training supports research at Brandeis University to discover the underlying mechanisms by which the endoplasmic reticulum (ER) chaperone GRP94 assists in the folding and secretion of insulin-like growth factor (IGF) proteins. The key objectives are to determine how and under what conditions IGF client proteins are transferred from the BIP...
This federal Project Grant award, with ID R35GM155240, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, totaling $1,248,750.00, aims to comprehensively elucidate the molecular and cellular mechanisms of the mitochondrial stress response in human cells. The research will leverage reporter-based assays, CRISPR screens, reconstituted cell-free assays, and proteomics approaches to...
This federal Project Grant award, valued at $342,342.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant supports a research program focused on developing and applying chemistry-enabled approaches to address critical questions in glycoscience. The key products and services to be delivered include: a) Generating and applying cell/tissue-selective reporters and inhibitors of...