Project Grant R01FD008217
Award Date
9/5/24
Completion Date
8/31/28
Dollars Obligated
$800K
Funding Federal Agency
Office of Medical Products and Tobacco
Awarding Federal Agency
FDA Office of Acquisition and Grant Services
Federal Grant Program
93.103
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $126,059 to the University of Colorado-Denver to explore the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD). The award aims to use "omics" technologies and high-dimensional data analysis to identify novel biomarkers and molecular pathways associated with...
This $1,284,920 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a multi-year study led by the Arkansas Children's Research Institute (ACRI) to optimize the use of a triple combination cystic fibrosis (CF) therapy. The study aims to: 1) analyze the pharmacokinetics of the three drug compounds in the therapy to determine their exposure-response relationship; 2) identify novel genetic variants...
This federal Project Grant award, with an ID of K23HD113816, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $163,080 award supports research to develop and validate longitudinal prediction models of new or worsening cardiovascular and respiratory dysfunction in critically ill, mechanically ventilated children. The research aims to leverage high-frequency physiological monitor...
This $844,386 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports genomic research to advance the understanding and treatment of childhood interstitial lung diseases (CHILD). The key objectives are to: Expand profiling of 300 CHILD lung biopsy samples to define patient subgroups based on molecular profiles, develop a CHILD classifier, and assess the clinical significance of the subgroups. Analyze...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to better understand the biomolecular mechanisms underlying lung hypoplasia in Congenital Diaphragmatic Hernia (CDH). The $544,924 award, made to The Johns Hopkins University, aims to investigate how reduced nuclear YAP/TAZ activation during fetal lung development contributes to the lung abnormalities observed...
This $339,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to comprehensively characterize the genetic basis of Hirschsprung's disease (HSCR), a rare congenital condition affecting the enteric nervous system. The research aims to leverage whole genome sequencing data from 766 HSCR cases and their family members to improve detection of all...
This Project Grant awarded by the Food and Drug Administration (FDA) under the FDA Research program (CFDA 93.103) provides $400,000.00 to The Children's Hospital of Philadelphia (CHOP) to accelerate clinical trials for Autosomal Recessive Polycystic Kidney Disease (ARPKD). The grant will fund the creation of PKDNET, a robust data resource to identify a research-ready cohort of children with ARPKD and collect high-quality natural history data. This will help define clinical outcomes and...
This $182,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program seeks to leverage data from three complementary sources - the NICHD-funded UCD Consortium natural history study, the Children's National Hospital clinical UCD expert center, and the legacy Tuchman Lab database - to correctly classify sequence variants in the OTC and NAGS genes associated with urea cycle...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) provides $790,989.00 to the Children's Research Institute to develop and evaluate the Family Centered (FACE-RARE) Pediatric Advance Care Planning intervention. The intervention is designed to address the palliative care needs and advance care planning for families with children who have rare diseases. Key...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), provides $744,305 to the University of Virginia to conduct research on the role of the transcription factor PHOX2B in maintaining the molecular, cellular, and network properties of intrinsically CO2/H+-sensitive retrotrapezoid nucleus (RTN) neurons. The research aims to: Examine how persistent expression of wild-type and CCHS-relevant...