This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to validate the performance of the DONATE machine learning model in predicting whether a pediatric patient will die within one hour after terminal extubation. The $286,820 award will also define facilitators and barriers to implementing the DONATE model and test the usability of a clinical decision...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $117,750 to the Ann & Robert H Lurie Children's Hospital of Chicago to develop and validate the use of wireless biosensors and a portable capnograph device for remote patient monitoring of children on long-term invasive home mechanical ventilation. The project aims to address limitations of the hospital's current hand-collected vital sign data approach by...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), funds the development and validation of a machine learning-based fetal monitoring system to predict and prevent fetal hypoxia. The $261,310 award will support the creation of a high-sensitivity, high-specificity predictive model using a multi-site dataset of 50,000 fetal monitoring tracings coupled with...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), part of the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $176,515 to Children's Hospital Los Angeles (CHLA) to investigate the relationship between alveolar dead space and new or progressive multiple organ dysfunction syndrome (NPMODS) in critically ill children. The key objectives are to: Identify the association between alveolar dead space and...
The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant, under the Child Health and Human Development Extramural Research program (CFDA 93.865), to Seattle Children's Hospital, doing business as Seattle Children's Research Institute, a non-profit organization. The $224,083 grant, awarded on May 1, 2025, will support research titled "USE OF OSCILLOMETRY FOR THE EVALUATION OF PULMONARY FUNCTION FOLLOWING PEDIATRIC ACUTE RESPIRATORY FAILURE." The...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 - Cardiovascular Diseases Research, provides $180,174 to The Children's Hospital of Philadelphia (CHOP) to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. The key objectives of this 5-year project are to: 1) compare heterogeneity of treatment effect analysis methodologies in a pediatric ARDS...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,070,206 to Ann & Robert H Lurie Children's Hospital of Chicago to conduct research on endotypes of bronchopulmonary dysplasia (BPD) in premature infants. The research aims to leverage existing genetic and longitudinal clinical data from approximately 2,000 former premature children to characterize the long-term...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $434,500 to the Research Institute at Nationwide Children's Hospital to develop an interpretable machine learning model that leverages maternal and infant electronic health record data to identify neonates in Level III NICUs who are most likely to benefit from early-life genome...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $866,579 to The Children's Hospital of Philadelphia (CHOP) to evaluate the effectiveness of an "Optimizing Ventilation (OPTI-VENT) Bundle" in improving cardiac arrest outcomes among children. The OPTI-VENT Bundle consists of provider education and...
The National Institute of Child Health and Human Development (NICHD) awarded a $261,168 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The objective of this 2-year award is to utilize advanced single-cell multi-omics techniques and machine learning approaches to investigate the cellular heterogeneity, dynamics, and...