Project Grant R01EY039107
- The National Eye Institute awarded the University of Rochester $684,914 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop human induced pluripotent stem cell (hiPSC)-derived retinal tissue models for disease research and cell-based therapeutic applications. The award funds two complementary aims. Aim 1 develops a microphysiological model of comprehensive hiPSC-derived retina that emulates the physiological spherical geometry of the human retina in vivo, suitable for...
- The National Eye Institute awarded Synvivo Inc. $290,400 on September 15, 2026, under the Vision Research program (CFDA 93.867) to develop the first standardized, commercial retinal barrier-on-chip using donor-matched human primary retinal pigment epithelial and choroidal endothelial cells for age-related macular degeneration (AMD) therapeutic testing. Synvivo will design and fabricate a retinal barrier-on-chip in a 3-plex array configuration integrating human choroidal endothelial cells...
- The National Eye Institute, part of the Department of Health and Human Services, awarded Vanderbilt University $435,875 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the mechanism of formation and cataractogenic properties of gamma-S-crystallin cleavage products. The research addresses cataract formation at the molecular level by elucidating how S-crystallin cleavage occurs in aging lenses and the functional consequences of such modification. The work...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Wisconsin–Madison $689,706 on August 1, 2026, under the Vision Research program (CFDA 93.867) to establish human stem cell-derived retinal organoids as functional models of human retina for studying disease and testing therapies. The award funds research to identify and overcome limitations in retinal organoids derived from human pluripotent stem cells....
- Federal Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2025 through May 31, 2027. The award funds research investigating the molecular mechanisms by which mutations in the ADAMTS10 gene contribute to primary open-angle glaucoma (POAG), a leading cause of irreversible blindness. The research employs genetically modified mouse models carrying...
- The National Eye Institute awarded The Schepens Eye Research Institute Inc. $506,030 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop an open-source solution for exporting and integrating optical coherence tomography data across institutions. The project addresses a critical barrier in ophthalmic research: OCT imaging data from multiple manufacturers is stored in over ten proprietary, undocumented formats with export tools that are prohibitively slow—exporting a...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
- The National Institutes of Health National Eye Institute awarded a $1.792 million Cooperative Agreement to the University of California, Los Angeles on September 1, 2026, under the Vision Research program (CFDA 93.867). The award funds development of adeno-associated virus vectors incorporating cell-type-specific cis-regulatory modules to target 23 distinct retinal cell types in primates, enabling precise labeling and functional manipulation of specific cells. The project aims to dissect...
- The National Eye Institute awarded $753,787 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop low-cost ultra-widefield retinal optical coherence tomography (OCT) technology based on photonic-electronic integration. The project addresses cost barriers that limit clinical availability of OCT instrumentation used to detect and monitor diabetic retinopathy, age-related macular...
The National Eye Institute awarded Vanderbilt University Medical Center $714,844 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop enabling technologies for pre-clinical and translational research using three-dimensional adult retina tissue culture. The award funds three technical aims: development of a custom scalable microfluidic platform integrated into air-liquid interface culture format to stabilize retinal tissue culture conditions and enable programmable control of factor delivery, multiplexing of test conditions, and imaging compatibility; development of dynamic contrast-optical coherence microscopy for cellular-resolution label-free imaging to enable longitudinal assessment of cell and tissue viability and morphological tracking without fluorescent reporters; and development of gene-specific fluorescent biosensors for cell tracking based on ADAR RNA editing. Work is performed at Forest Hills, Tennessee, with performance running through August 31, 2030. The project directly addresses barriers to widespread adoption of 3D retina cultures in disease modeling, drug testing, and regenerative medicine, including unstable environmental conditions, slow iteration of test conditions, reliance on endpoint analysis, and challenges in monitoring viability and tracking live cells.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $714.8k | 8/31/26 |