Project Grant R01EY038076
- The National Eye Institute awarded the University of Rochester $684,914 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop human induced pluripotent stem cell (hiPSC)-derived retinal tissue models for disease research and cell-based therapeutic applications. The award funds two complementary aims. Aim 1 develops a microphysiological model of comprehensive hiPSC-derived retina that emulates the physiological spherical geometry of the human retina in vivo, suitable for...
- The National Eye Institute, part of the Department of Health and Human Services, awarded $458,288 to the University of Washington on May 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing designation Project Grant). The award funds research into stimulation of regeneration in the human retina. The investigator team will test whether expressing the proneural regulatory gene ASCL1 in Müller glia can induce regeneration of retinal neurons in human tissue and adult non-human...
- The National Eye Institute awarded the University of Wisconsin–Madison $249,672 under the Vision Research program (CFDA 93.867) on May 8, 2026, to support a project grant investigating light adaptation in regionally and functionally distinct retinal circuits. The project examines how the primate retina modulates neural response gain and kinetics across changing light conditions, with specific focus on foveal versus peripheral regions and on versus off visual pathways. Aim 1 determines the impact...
- The National Eye Institute, within the Department of Health and Human Services National Institutes of Health, awarded $122,610 to University of Wisconsin–Madison on December 3, 2025, under the Vision Research program (CFDA 93.867) to conduct research on synaptic ribbon contributions to retinal circuit function and assembly. The research measures synaptic inputs to on-sustained and off-sustained alpha ganglion cells in a ribbon loss-of-function mouse model to determine whether ribbons regulate...
- The National Eye Institute awarded the University of Washington $622,804 under the Vision Research program (CFDA 93.867) on August 1, 2026, to establish the cellular and molecular basis of the cone optoretinogram and standardize methods for clinical application. The cone optoretinogram measures length changes of individual human cone outer segments at nanometer-millisecond scale in response to light, using adaptive optics and optical coherence tomography. The research aims to develop...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Washington $427,625 on June 1, 2026, under the Vision Research program (CFDA 93.867, Assistance Listing Project Grant R21EY038886). The award funds research to decode time-dependent nonlinearities underlying retinal responses to natural stimuli, with particular emphasis on bipolar cell synapses and their role in synaptic plasticity and pathway convergence....
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $100,228 on December 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct preclinical research on autologous transplantation of genetically modified induced pluripotent stem cells (iPSCs) to treat autosomal dominant retinal disorders, specifically RPE65 D477G mutations causing retinitis...
- The National Eye Institute awarded Duke University $405,373 on June 1, 2026, under the Vision Research program (CFDA 93.867) to characterize bicornuate cones, a novel type of cone photoreceptor cell discovered in the human retina that contains two fully developed outer segments emanating from a single inner segment. The project will conduct two specific aims. Aim 1 employs high-resolution ultrastructural analysis using three-dimensional electron tomography to determine the number of centrioles...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Medical College of Wisconsin, Inc. $564,849 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate how prior experience shapes visual selectivity within the human ventral temporal cortex. The project integrates single-unit neural recordings, local field potential, and functional magnetic resonance imaging to identify factors determining visual...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Wisconsin–Madison $689,706 on August 1, 2026, under the Vision Research program (CFDA 93.867) to establish human stem cell-derived retinal organoids as functional models of human retina for studying disease and testing therapies. The award funds research to identify and overcome limitations in retinal organoids derived from human pluripotent stem cells. Specifically, the work addresses constraints in cone photoreceptor signaling at the level of signal transduction and transmission across the photoreceptor synapse to downstream neural circuitry. The project includes three aims: determining the relative contributions of cone photoreceptor-extrinsic, cone photoreceptor-intrinsic, and developmental factors limiting uniform populations of functional cones with robust phototransduction profiles; delineating reliable transmission of electrical signaling between cone photoreceptors and second-order neurons using anatomical, electrophysiological, and genetic approaches; and leveraging patient-derived and gene-edited retinal organoids to model distinct retinal diseases affecting cone signaling for dose-dependent gene therapy testing. Work is performed in Madison, Wisconsin. The period of performance runs through July 31, 2030. This is a project grant, a non-renewable assistance type under NEI's Vision Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.7k | 8/4/26 |